InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DMD

Summary

InnateDB Protein

IDBP-54157.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DMD

Protein Name

dystrophin

Synonyms

BMD; CMD3B; DXS142; DXS164; DXS206; DXS230; DXS239; DXS268; DXS269; DXS270; DXS272; MRX85;

Species

Homo sapiens

Ensembl Protein

ENSP00000367951

InnateDB Gene

IDBG-54131 (DMD)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.

Experimentally validated
Total	34 [view]
Protein-Protein	33 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	21 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002162	dystroglycan binding
GO:0003779	actin binding
GO:0005200	structural constituent of cytoskeleton
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0008307	structural constituent of muscle
GO:0017022	myosin binding
GO:0017166	vinculin binding
GO:0050998	nitric-oxide synthase binding

Biological Process

GO:0002027	regulation of heart rate
GO:0007517	muscle organ development
GO:0010880	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
GO:0010881	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
GO:0010976	positive regulation of neuron projection development
GO:0014809	regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion
GO:0014819	regulation of skeletal muscle contraction
GO:0030049	muscle filament sliding
GO:0030198	extracellular matrix organization
GO:0033137	negative regulation of peptidyl-serine phosphorylation
GO:0034613	cellular protein localization
GO:0043043	peptide biosynthetic process
GO:0043623	cellular protein complex assembly
GO:0044458	motile cilium assembly
GO:0045666	positive regulation of neuron differentiation
GO:0060048	cardiac muscle contraction
GO:0060314	regulation of ryanodine-sensitive calcium-release channel activity
GO:0086001	cardiac muscle cell action potential
GO:0090287	regulation of cellular response to growth factor stimulus
GO:1901385	regulation of voltage-gated calcium channel activity
GO:1902083	negative regulation of peptidyl-cysteine S-nitrosylation
GO:2000651	positive regulation of sodium ion transmembrane transporter activity

Cellular Component

GO:0005634	nucleus
GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0015629	actin cytoskeleton
GO:0016010	dystrophin-associated glycoprotein complex
GO:0016013	syntrophin complex
GO:0016328	lateral plasma membrane
GO:0030054	cell junction
GO:0030175	filopodium
GO:0031527	filopodium membrane
GO:0042383	sarcolemma
GO:0043034	costamere
GO:0043234	protein complex
GO:0045121	membrane raft
GO:0045211	postsynaptic membrane