Version 5.4
Homo sapiens Protein: SNX4
Summary
InnateDB Protein IDBP-54198.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SNX4
Protein Name sorting nexin 4
Synonyms ATG24B;
Species Homo sapiens
Ensembl Protein ENSP00000251775
InnateDB Gene IDBG-54196 (SNX4)
Protein Structure
UniProt Annotation
Function May be involved in several stages of intracellular trafficking. Plays a role in recycling endocytosed transferrin receptor and prevent its degradation. {ECO:0000269PubMed:17994011}.
Subcellular Localization Early endosome membrane {ECO:0000269PubMed:17994011}; Peripheral membrane protein {ECO:0000269PubMed:17994011}; Cytoplasmic side {ECO:0000269PubMed:17994011}. Note=Also detected on a juxtanuclear endocytic recycling compartment (ERC).
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
Experimentally validated
Total 26 [view]
Protein-Protein 26 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0035091 phosphatidylinositol binding
Biological Process
GO:0006886 intracellular protein transport
GO:0006897 endocytosis
GO:0015031 protein transport
GO:0032456 endocytic recycling
Cellular Component
GO:0005737 cytoplasm
GO:0005868 cytoplasmic dynein complex
GO:0031901 early endosome membrane
Protein Structure and Domains
PDB ID
InterPro IPR001683 Phox homologous domain
PFAM PF00787
PRINTS
PIRSF
SMART SM00312
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O95219
PhosphoSite PhosphoSite-O95219
TrEMBL Q9H398
UniProt Splice Variant
Entrez Gene 8723
UniGene Hs.507243
RefSeq NP_003785
HUGO HGNC:11175
OMIM 605931
CCDS CCDS3032
HPRD 09334
IMGT
EMBL AC080096 AC117487 AF065485 AF130078 AK001835 AK298972 BC018762 CH471052
GenPept AAC83149 AAG35504 AAH18762 BAG50982 BAG61066 EAW79390 EAW79391 EAW79393

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca