Homo sapiens Gene: SNX4
Summary
InnateDB Gene IDBG-54196.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SNX4
Gene Name sorting nexin 4
Synonyms ATG24B;
Species Homo sapiens
Ensembl Gene ENSG00000114520
Encoded Proteins
sorting nexin 4
sorting nexin 4
sorting nexin 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein associated with the long isoform of the leptin receptor and with receptor tyrosine kinases for platelet-derived growth factor, insulin, and epidermal growth factor in cell cultures, but its function is unknown. This protein may form oligomeric complexes with family members. Two transcript variants, one protein coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Nov 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:125446644-125520197
Strand Reverse strand
Band q21.2
Transcripts
ENST00000251775 ENSP00000251775
ENST00000471751 ENSP00000420526
ENST00000482965
ENST00000473417
ENST00000465505 ENSP00000420175
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
Experimentally validated
Total 26 [view]
Protein-Protein 26 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0035091 phosphatidylinositol binding
Biological Process
GO:0006886 intracellular protein transport
GO:0006897 endocytosis
GO:0015031 protein transport
GO:0032456 endocytic recycling
Cellular Component
GO:0005737 cytoplasm
GO:0005868 cytoplasmic dynein complex
GO:0031901 early endosome membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
TGF_beta_Receptor pathway
REACTOME
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL F8WDD4
UniProt Splice Variant
Entrez Gene 8723
UniGene Hs.507243
RefSeq NM_003794
HUGO HGNC:11175
OMIM 605931
CCDS CCDS3032
HPRD 09334
IMGT
EMBL AC080096 AC117487
GenPept
RNA Seq Atlas 8723