Version 5.4
Mus musculus Protein: Prlr
Summary
InnateDB Protein IDBP-541987.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Prlr
Protein Name prolactin receptor
Synonyms AI987712; Pr-1; Pr-3; Prlr-rs1;
Species Mus musculus
Ensembl Protein ENSMUSP00000121280
InnateDB Gene IDBG-129218 (Prlr)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 20 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004925 prolactin receptor activity
GO:0005515 protein binding
Biological Process
GO:0007259 JAK-STAT cascade
GO:0007595 lactation
GO:0030155 regulation of cell adhesion
GO:0030856 regulation of epithelial cell differentiation
GO:0038161 prolactin signaling pathway
GO:0060644 mammary gland epithelial cell differentiation
GO:0060736 prostate gland growth
GO:0060749 mammary gland alveolus development
GO:0061180 mammary gland epithelium development
Cellular Component
GO:0016020 membrane
Protein Structure and Domains
PDB ID MGI:97763
InterPro IPR003961 Fibronectin, type III
IPR015152 Growth hormone/erythropoietin receptor, ligand binding
IPR015321 Interleukin-6 receptor alpha, binding
PFAM PF00041
PF01108
PF09067
PF09240
PRINTS
PIRSF
SMART SM00060
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL Q8C9F9
UniProt Splice Variant
Entrez Gene 19116
UniGene Mm.442446
RefSeq NP_001240710
MGI ID
MGI Symbol Prlr
OMIM
CCDS CCDS56976
HPRD
IMGT
EMBL AB643813 AC102101 AC163998 AC163999 AK042147 CH466581
GenPept BAC31184 BAL45579 EDL03307

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca