Version 5.4
Homo sapiens Protein: OSBPL11
Summary
InnateDB Protein IDBP-54222.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol OSBPL11
Protein Name oxysterol binding protein-like 11
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000296220
InnateDB Gene IDBG-54220 (OSBPL11)
Protein Structure
UniProt Annotation
Function
Subcellular Localization Late endosome membrane {ECO:0000269PubMed:20599956}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269PubMed:20599956}. Note=Localizes at the Golgi-late endosome interface.
Disease Associations
Tissue Specificity Present at highest levels in ovary, testis, kidney, liver, stomach, brain, and adipose tissue. Strong expression (at protein level) in epithelial cells of kidney tubules, testicular tubules, caecum, and skin. {ECO:0000269PubMed:20599956}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
Experimentally validated
Total 13 [view]
Protein-Protein 12 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008289 lipid binding
Biological Process
GO:0006869 lipid transport
GO:0010890 positive regulation of sequestering of triglyceride
GO:0045444 fat cell differentiation
Cellular Component
GO:0005794 Golgi apparatus
GO:0031902 late endosome membrane
Protein Structure and Domains
PDB ID
InterPro IPR000648 Oxysterol-binding protein
IPR001849 Pleckstrin homology domain
PFAM PF01237
PF00169
PRINTS
PIRSF
SMART SM00233
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9BXB4
PhosphoSite PhosphoSite-Q9BXB4
TrEMBL Q9GZM0
UniProt Splice Variant
Entrez Gene 114885
UniGene Hs.701305
RefSeq NP_073613
HUGO HGNC:16397
OMIM 606739
CCDS CCDS3033
HPRD 09481
IMGT
EMBL AF346292 AF392454 AK023074 AK023226 AK292702 BC010422 BC065213 CH471052
GenPept AAH10422 AAH65213 AAK31141 AAL40667 BAB14391 BAB14477 BAF85391 EAW79389

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca