InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ift20

Summary

InnateDB Protein

IDBP-542315.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ift20

Protein Name

intraflagellar transport 20 homolog (Chlamydomonas)

Synonyms

0610009H04Rik; AU015496;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000118015

InnateDB Gene

IDBG-203058 (Ift20)

Protein Structure

UniProt Annotation

Function

Part of intraflagellar transport (IFT) particles involved in ciliary process assembly. May play a role in the trafficking of ciliary membrane proteins from the Golgi complex to the cilium. Also involved in autophagy since it is required for trafficking of ATG16L and the expansion of the autophagic compartment. {ECO:0000269PubMed:16775004, ECO:0000269PubMed:24089209}.

Subcellular Localization

Golgi apparatus, cis-Golgi network. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, cilium basal body. Note=Present at the centrosomes during the cell cycle and associated with the proximal portion of the mother centriole and the lateral aspect of the daughter centriole. Associated with basal body at the base of primary cilia.

Disease Associations

Tissue Specificity

Expressed in testis, kidney and retina. {ECO:0000269PubMed:11916979, ECO:0000269PubMed:12821668}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002046	opsin binding
GO:0005515	protein binding

Biological Process

GO:0001822	kidney development
GO:0007224	smoothened signaling pathway
GO:0008542	visual learning
GO:0022008	neurogenesis
GO:0034067	protein localization to Golgi apparatus
GO:0035845	photoreceptor cell outer segment organization
GO:0036372	opsin transport
GO:0042073	intraciliary transport
GO:0042384	cilium assembly
GO:0051642	centrosome localization
GO:0055007	cardiac muscle cell differentiation
GO:0060828	regulation of canonical Wnt signaling pathway
GO:0061351	neural precursor cell proliferation
GO:0061512	protein localization to cilium
GO:1902017	regulation of cilium assembly
GO:2000785	regulation of autophagic vacuole assembly

Cellular Component

GO:0001750	photoreceptor outer segment
GO:0005794	Golgi apparatus
GO:0005813	centrosome
GO:0005814	centriole
GO:0005929	cilium
GO:0030992	intraciliary transport particle B
GO:0031514	motile cilium
GO:0032391	photoreceptor connecting cilium
GO:0036064	ciliary basal body
GO:0044292	dendrite terminus
GO:0070062	extracellular vesicular exosome
GO:0072372	primary cilium
GO:0097546	ciliary base