InnateDB Protein
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IDBP-54243.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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ACTR2
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Protein Name
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ARP2 actin-related protein 2 homolog (yeast)
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Synonyms
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ARP2;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000260641
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InnateDB Gene
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IDBG-54239 (ACTR2)
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Protein Structure
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Function |
Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament. {ECO:0000269PubMed:9000076}.
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Subcellular Localization |
Cytoplasm, cytoskeleton {ECO:0000269PubMed:9000076}. Cell projection {ECO:0000269PubMed:9000076}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 79 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
79
[view]
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Protein-Protein |
79
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR004000
Actin-related protein
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PFAM |
PF00022
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PRINTS |
PR00190
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PIRSF |
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SMART |
SM00268
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TIGRFAMs |
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Modification |
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SwissProt |
P61160
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PhosphoSite |
PhosphoSite-P61160
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
10097
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UniGene |
Hs.728857
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RefSeq |
NP_005713
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HUGO |
HGNC:169
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OMIM |
604221
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CCDS |
CCDS1881
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HPRD |
05023
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IMGT |
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EMBL |
AC007318
AF006082
AK315205
BC014546
BX649080
CH471053
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GenPept |
AAB64187
AAH14546
BAG37642
EAW99908
EAW99910
EAW99912
EAW99913
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