Homo sapiens Gene: ACTR2
Summary
InnateDB Gene IDBG-54239.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ACTR2
Gene Name ARP2 actin-related protein 2 homolog (yeast)
Synonyms ARP2;
Species Homo sapiens
Ensembl Gene ENSG00000138071
Encoded Proteins
ARP2 actin-related protein 2 homolog (yeast)
ARP2 actin-related protein 2 homolog (yeast)
ARP2 actin-related protein 2 homolog (yeast)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The specific function of this gene has not yet been determined; however, the protein it encodes is known to be a major constituent of the ARP2/3 complex. This complex is located at the cell surface and is essential to cell shape and motility through lamellipodial actin assembly and protrusion. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:65227753-65271253
Strand Forward strand
Band p14
Transcripts
ENST00000377982 ENSP00000367220
ENST00000260641 ENSP00000260641
ENST00000476840
ENST00000471552
ENST00000542850 ENSP00000437383
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 79 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 79 [view]
Protein-Protein 79 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005524 ATP binding
Biological Process
GO:0006928 cellular component movement
GO:0007163 establishment or maintenance of cell polarity
GO:0008356 asymmetric cell division
GO:0016344 meiotic chromosome movement towards spindle pole
GO:0016482 cytoplasmic transport
GO:0030036 actin cytoskeleton organization
GO:0033206 cytokinesis after meiosis
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0045087 innate immune response
GO:0051321 meiotic cell cycle
GO:0051653 spindle localization
Cellular Component
GO:0005829 cytosol
GO:0005885 Arp2/3 protein complex
GO:0005938 cell cortex
GO:0015629 actin cytoskeleton
GO:0016020 membrane
GO:0030478 actin cap
GO:0042995 cell projection
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
EGFR1 pathway
KitReceptor pathway
REACTOME
Regulation of actin dynamics for phagocytic cup formation pathway
Developmental Biology pathway
EPHB-mediated forward signaling pathway
Innate Immune System pathway
Axon guidance pathway
Immune System pathway
Fcgamma receptor (FCGR) dependent phagocytosis pathway
EPH-Ephrin signaling pathway
KEGG
INOH
PID BIOCARTA
Y branching of actin filaments [Biocarta view]
How does salmonella hijack a cell [Biocarta view]
Role of pi3k subunit p85 in regulation of actin organization and cell migration [Biocarta view]
PID NCI
ErbB1 downstream signaling
RAC1 signaling pathway
CDC42 signaling events
PDGFR-beta signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.728857
RefSeq NM_001005386 NM_005722
HUGO
OMIM
CCDS CCDS1881 CCDS46307
HPRD 05023
IMGT
EMBL
GenPept
RNA Seq Atlas