InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ACTR2

Summary

InnateDB Gene

IDBG-54239.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ACTR2

Gene Name

ARP2 actin-related protein 2 homolog (yeast)

Synonyms

ARP2

Species

Homo sapiens

Ensembl Gene

ENSG00000138071

Encoded Proteins

IDBP-54241

ARP2 actin-related protein 2 homolog (yeast)

IDBP-54243

ARP2 actin-related protein 2 homolog (yeast)

IDBP-601054

ARP2 actin-related protein 2 homolog (yeast)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The specific function of this gene has not yet been determined; however, the protein it encodes is known to be a major constituent of the ARP2/3 complex. This complex is located at the cell surface and is essential to cell shape and motility through lamellipodial actin assembly and protrusion. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:65227753-65271253

Strand

Forward strand

Band

p14

Transcripts

ENST00000377982	ENSP00000367220
ENST00000260641	ENSP00000260641
ENST00000476840
ENST00000471552
ENST00000542850	ENSP00000437383

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 79 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	79 [view]
Protein-Protein	79 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005524	ATP binding

Biological Process

GO:0006928	cellular component movement
GO:0007163	establishment or maintenance of cell polarity
GO:0008356	asymmetric cell division
GO:0016344	meiotic chromosome movement towards spindle pole
GO:0016482	cytoplasmic transport
GO:0030036	actin cytoskeleton organization
GO:0033206	cytokinesis after meiosis
GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0045087	innate immune response
GO:0051321	meiotic cell cycle
GO:0051653	spindle localization

Cellular Component

GO:0005829	cytosol
GO:0005885	Arp2/3 protein complex
GO:0005938	cell cortex
GO:0015629	actin cytoskeleton
GO:0016020	membrane
GO:0030478	actin cap
GO:0042995	cell projection
GO:0070062	extracellular vesicular exosome