InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Aanat

Summary

InnateDB Protein

IDBP-542458.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Aanat

Protein Name

arylalkylamine N-acetyltransferase

Synonyms

AA-NAT; Nat-2; Nat4; Snat;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000122895

InnateDB Gene

IDBG-214486 (Aanat)

Protein Structure

UniProt Annotation

Function

Controls the night/day rhythm of melatonin production in the pineal gland. Catalyzes the N-acetylation of serotonin into N- acetylserotonin, the penultimate step in the synthesis of melatonin.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Highly expressed in pineal gland at night. Expression in the retina has not been confirmed. Extrapineal expression could be strain-specific. {ECO:0000269PubMed:9838107}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004059	aralkylamine N-acetyltransferase activity
GO:0004060	arylamine N-acetyltransferase activity
GO:0008080	N-acetyltransferase activity
GO:0071889	14-3-3 protein binding

Biological Process

GO:0006474	N-terminal protein amino acid acetylation
GO:0007623	circadian rhythm
GO:0009416	response to light stimulus
GO:0010043	response to zinc ion
GO:0014070	response to organic cyclic compound
GO:0030187	melatonin biosynthetic process
GO:0032868	response to insulin
GO:0034097	response to cytokine
GO:0034695	response to prostaglandin E
GO:0046688	response to copper ion
GO:0051412	response to corticosterone
GO:0051591	response to cAMP
GO:0051592	response to calcium ion
GO:0071320	cellular response to cAMP