Version 5.4
Mus musculus Protein: Kitl
Summary
InnateDB Protein IDBP-542483.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Kitl
Protein Name kit ligand
Synonyms blz; Clo; Con; contrasted; Gb; Kitlg; Mgf; SCF; SF; Sl; SLF;
Species Mus musculus
Ensembl Protein ENSMUSP00000123360
InnateDB Gene IDBG-187862 (Kitl)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
GO:0005173 stem cell factor receptor binding
GO:0005515 protein binding
Biological Process
GO:0001755 neural crest cell migration
GO:0002763 positive regulation of myeloid leukocyte differentiation
GO:0007155 cell adhesion
GO:0007281 germ cell development
GO:0008284 positive regulation of cell proliferation
GO:0033026 negative regulation of mast cell apoptotic process
GO:0035234 ectopic germ cell programmed cell death
GO:0043066 negative regulation of apoptotic process
GO:0043406 positive regulation of MAP kinase activity
GO:0045087 innate immune response (InnateDB)
GO:0045636 positive regulation of melanocyte differentiation
GO:0046579 positive regulation of Ras protein signal transduction
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0070668 positive regulation of mast cell proliferation
GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand
Cellular Component
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:96974
InterPro IPR003452 Stem cell factor
IPR009079 Four-helical cytokine-like, core
PFAM PF02404
PRINTS
PIRSF PIRSF015599
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL Q8C9K1
UniProt Splice Variant
Entrez Gene 17311
UniGene Mm.456756
RefSeq
MGI ID
MGI Symbol Kitl
OMIM
CCDS
HPRD
IMGT
EMBL AC159910 AK041961
GenPept BAC31113

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca