InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Unc93b1

Summary

InnateDB Protein

IDBP-542745.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Unc93b1

Protein Name

unc-93 homolog B1 (C. elegans)

Synonyms

Unc-93B1; Unc93b;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000124272

InnateDB Gene

IDBG-128581 (Unc93b1)

Protein Structure

UniProt Annotation

Function

Plays an important role in innate and adaptive immunity by regulating nucleotide-sensing Toll-like receptor (TLR) signaling. Required for the transport of a subset of TLRs (including TLR3, TLR7 and TLR9) from the endoplasmic reticulum to endolysosomes where they can engage pathogen nucleotides and activate signaling cascades. May play a role in autoreactive B- cells removal. {ECO:0000269PubMed:16415873, ECO:0000269PubMed:17452530, ECO:0000269PubMed:18305481}.

Subcellular Localization

Endoplasmic reticulum membrane; Multi-pass membrane protein. Endosome. Lysosome. Cytoplasmic vesicle, phagosome. Note=Colocalizes with LAMP5 in large endosomal intracellular vesicles (By similarity). Relocalizes from endoplasmic reticulum to endosome and lysosome upon cell- stimulation with CpG dinucleotides. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 29 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	14 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	29 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0035325	Toll-like receptor binding

Biological Process

GO:0002224	toll-like receptor signaling pathway
GO:0006886	intracellular protein transport
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0034138	toll-like receptor 3 signaling pathway
GO:0034154	toll-like receptor 7 signaling pathway
GO:0034162	toll-like receptor 9 signaling pathway
GO:0045087	innate immune response (InnateDB)
GO:0051607	defense response to virus

Cellular Component

GO:0005764	lysosome
GO:0005768	endosome
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0016021	integral component of membrane
GO:0032009	early phagosome