InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Unc93b1

Summary

InnateDB Gene

IDBG-128581.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Unc93b1

Gene Name

unc-93 homolog B1 (C. elegans)

Synonyms

Unc-93B1; Unc93b

Species

Mus musculus

Ensembl Gene

ENSMUSG00000036908

Encoded Proteins

IDBP-542745

unc-93 homolog B1 (C. elegans)

IDBP-619800

unc-93 homolog B1 (C. elegans)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21097503

Unc93b1 is a resident endoplasmic reticulum protein that interacts with Tlr11 to regulate the dendritic cell activation in response to T. gondii profilin and parasitic infection.

PMID 21683627

Unc93b1 controls homeostatic Tlr7 activation by balancing Tlr9 to Tlr7 trafficking from endoplasmic reticulum to endolysosomes. D34A mutation in Unc93b1 causes Tlr7-dependent systemic lethal inflammation.

PMID 21683627

Unc93B1 is a multitransmembrane endoplasmic reticulum (ER)-resident protein that controls homeostatic Tlr7 activation by balancing Tlr9 to Tlr7 trafficking. Mice harboring a D34A mutation in Unc93b1 show Tlr7-dependent, systemic lethal inflammation.

PMID 22164301

Unc93b1 participates in intracellular trafficking and signalling for all nucleotide-sensing Toll-like receptors (TLRs ). (Demonstrated in human)

InnateDB Annotation from Orthologs

Summary

PMID 18305481

[Homo sapiens] UNC93B1 is a polytopic membrane protein that delivers the nucleotide sensing receptors TLR7 and TLR9 from the endoplasmic reticulum to endolysosomes.

PMID 19451267

[Homo sapiens] UNC93B1 biases Toll-like receptor responses to nucleic acid in dendritic cells toward DNA- but against RNA-sensing.

PMID 20865117

[Homo sapiens] UNC93B1 associates with Toll-Like Receptor (TLR) 3, TLR7 and TLR9, mediating their translocation from the endoplasmic reticulum to the endolysosome, hence allowing proper activation by nucleic acid ligands. UNC93B1 has a critical role on induction of IL-12/IFN-gamma production as well as autonomous control of Toxoplasma replication by macrophages.

PMID 21683627

[Homo sapiens] UNC93B1 controls homeostatic TLR7 activation by balancing TLR9 to TLR7 trafficking from endoplasmic reticulum to endolysosomes. D34A mutation in UNC93B1 causes TLR7-dependent systemic lethal inflammation. (Demonstrated in murine model)

PMID 21683627

[Homo sapiens] UNC93B1 is a multitransmembrane endoplasmic reticulum (ER)-resident protein that controls homeostatic TLR7 activation by balancing TLR9 to TLR7 trafficking. Mice harboring a D34A mutation in Unc93b1 show Tlr7-dependent, systemic lethal inflammation.

PMID 22164301

[Homo sapiens] UNC93B1 participates in intracellular trafficking and signalling for all nucleotide-sensing Toll-like receptors (TLRs).

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000110057:
This gene encodes a protein with similarity to the C. elegans unc93 protein. The Unc93 protein is involved in the regulation or coordination of muscle contraction in the worm. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:3935186-3949340

Strand

Forward strand

Band

Transcripts

ENSMUST00000162708	ENSMUSP00000124272
ENSMUST00000162193
ENSMUST00000161415
ENSMUST00000165711	ENSMUSP00000128751

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 29 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	14 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	29 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0035325	Toll-like receptor binding

Biological Process

GO:0002224	toll-like receptor signaling pathway
GO:0006886	intracellular protein transport
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0034138	toll-like receptor 3 signaling pathway
GO:0034154	toll-like receptor 7 signaling pathway
GO:0034162	toll-like receptor 9 signaling pathway
GO:0045087	innate immune response (InnateDB)
GO:0051607	defense response to virus

Cellular Component

GO:0005764	lysosome
GO:0005768	endosome
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0016021	integral component of membrane
GO:0032009	early phagosome

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000110057

View Gene Order

ENSBTAG00000001193

Not yet available

Pathways

NETPATH

REACTOME

REACT_239142

Innate Immune System pathway

REACT_198976

Trafficking and processing of endosomal TLR pathway

REACT_230745

Immune System pathway

REACT_251547

Toll-Like Receptors Cascades pathway

KEGG

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_118632

Trafficking and processing of endosomal TLR pathway

REACT_6802

Innate Immune System pathway

REACT_6966

Toll-Like Receptors Cascades pathway

REACT_6900

Immune System pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

Q8VCW4

TrEMBL

E9PYK0

UniProt Splice Variant

Entrez Gene

54445

UniGene

RefSeq

NM_019449 NM_001161428

OMIM

CCDS

CCDS29404 CCDS50346

HPRD

IMGT

MGI ID

MGI:1859307

MGI Symbol

Unc93b1

EMBL

AC133523 AJ422144 AK165060 BC018388 BC023731 BC025587 U89424

GenPept

AAC36530 AAH18388 AAH23731 AAH25587 BAE38019 CAD19524

RNA Seq Atlas

54445