InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Crem

Summary

InnateDB Protein

IDBP-542976.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Crem

Protein Name

cAMP responsive element modulator

Synonyms

ICER; ICERI;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000121233

InnateDB Gene

IDBG-127729 (Crem)

Protein Structure

UniProt Annotation

Function

Transcriptional regulator that binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. Isoforms are either transcriptional activators or repressors. Isoform 2, isoform 3 and isoform 4 are repressors, while isoform 1 is an activator. Plays a role in spermatogenesis and is involved in spermatid maturation. Binding of isoform 1 (activator) to CRE is increased by CREB3L4. The CREM isoform 1- CREB3L4 heterodimer functions through CRE and may recruit HIRA to CRE to regulate histone exchange (PubMed:16595651). {ECO:0000269PubMed:16595651}.Isoform 11: Plays a role in the regulation of the circadian clock: acts as a transcriptional repressor of the core circadian component PER1 by directly binding to cAMP response elements in its promoter. {ECO:0000269PubMed:16595651, ECO:0000269PubMed:23443664}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:23443664, ECO:0000269PubMed:8252624}.Isoform 11: Cytoplasm. Nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	16 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006687	glycosphingolipid metabolic process
GO:0007283	spermatogenesis
GO:0045944	positive regulation of transcription from RNA polymerase II promoter