Version 5.4
Mus musculus Gene: Crem
Summary
InnateDB Gene IDBG-127729.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Crem
Gene Name cAMP responsive element modulator
Synonyms ICER; ICERI
Species Mus musculus
Ensembl Gene ENSMUSG00000063889
Encoded Proteins
IDBP-127733
cAMP responsive element modulator
IDBP-127735
cAMP responsive element modulator
IDBP-127737
cAMP responsive element modulator
IDBP-542973
cAMP responsive element modulator
IDBP-542976
cAMP responsive element modulator
IDBP-542977
cAMP responsive element modulator
IDBP-542978
cAMP responsive element modulator
IDBP-542979
cAMP responsive element modulator
IDBP-542980
cAMP responsive element modulator
IDBP-542981
cAMP responsive element modulator
IDBP-542982
cAMP responsive element modulator
IDBP-542983
cAMP responsive element modulator
IDBP-542984
cAMP responsive element modulator
IDBP-542985
cAMP responsive element modulator
IDBP-542986
cAMP responsive element modulator
IDBP-542987
cAMP responsive element modulator
IDBP-542988
cAMP responsive element modulator
IDBP-542989
cAMP responsive element modulator
IDBP-542990
cAMP responsive element modulator
IDBP-542991
cAMP responsive element modulator
IDBP-542992
cAMP responsive element modulator
IDBP-542993
cAMP responsive element modulator
IDBP-542994
cAMP responsive element modulator
IDBP-542996
cAMP responsive element modulator
IDBP-542997
cAMP responsive element modulator
IDBP-542998
cAMP responsive element modulator
IDBP-542999
cAMP responsive element modulator
IDBP-543000
cAMP responsive element modulator
IDBP-543001
cAMP responsive element modulator
IDBP-543002
cAMP responsive element modulator
IDBP-543003
cAMP responsive element modulator
IDBP-543004
cAMP responsive element modulator
IDBP-543005
cAMP responsive element modulator
IDBP-621125
cAMP responsive element modulator
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a basic-leucine zipper domain-containing protein that localizes to gene promoters, where it binds to the cyclic AMP response element (CRE). Different protein isoforms encoded by this gene may function as either activators or repressors of transcription. Activity of this gene is important in multiple developmental processes, including spermatogenesis. Mutation of this gene causes male infertility. Alternative splicing and promoter usage result in multiple transcript variants for this gene. [provided by RefSeq, Oct 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:3266048-3337748
Strand Reverse strand
Band A1
Transcripts
ENSMUST00000082141 ENSMUSP00000080780
ENSMUST00000025069 ENSMUSP00000025069
ENSMUST00000049942 ENSMUSP00000061925
ENSMUST00000151311 ENSMUSP00000118267
ENSMUST00000150235 ENSMUSP00000121233
ENSMUST00000154135 ENSMUSP00000122051
ENSMUST00000122958 ENSMUSP00000121118
ENSMUST00000140332 ENSMUSP00000115423
ENSMUST00000140912
ENSMUST00000154470 ENSMUSP00000118128
ENSMUST00000129435 ENSMUSP00000117438
ENSMUST00000151084 ENSMUSP00000118578
ENSMUST00000131899 ENSMUSP00000119353
ENSMUST00000130599 ENSMUSP00000115471
ENSMUST00000124747 ENSMUSP00000121352
ENSMUST00000127601 ENSMUSP00000118649
ENSMUST00000147138 ENSMUSP00000114280
ENSMUST00000156234 ENSMUSP00000121388
ENSMUST00000152900 ENSMUSP00000123515
ENSMUST00000134027 ENSMUSP00000122557
ENSMUST00000130455 ENSMUSP00000121541
ENSMUST00000137568 ENSMUSP00000115336
ENSMUST00000146265 ENSMUSP00000119638
ENSMUST00000123672 ENSMUSP00000120557
ENSMUST00000152108 ENSMUSP00000122241
ENSMUST00000136961 ENSMUSP00000115363
ENSMUST00000144496 ENSMUSP00000120349
ENSMUST00000139537 ENSMUSP00000122123
ENSMUST00000148305 ENSMUSP00000115938
ENSMUST00000154705 ENSMUSP00000119194
ENSMUST00000126578 ENSMUSP00000114780
ENSMUST00000154715 ENSMUSP00000122179
ENSMUST00000149266
ENSMUST00000130047
ENSMUST00000156929
ENSMUST00000149803 ENSMUSP00000121210
ENSMUST00000142690 ENSMUSP00000122282
ENSMUST00000132334
ENSMUST00000165086 ENSMUSP00000127353
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 16 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006687 glycosphingolipid metabolic process
GO:0007283 spermatogenesis
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0005634 nucleus
GO:0005667 transcription factor complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000095794
View Gene Order
ENSBTAG00000016060
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_23
TSH pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt P27699
TrEMBL
UniProt Splice Variant
Entrez Gene 12916
UniGene Mm.398386 Mm.414098 Mm.489069 Mm.5244
RefSeq NM_001110857 NM_001110850 NM_001110851 NM_001110852 NM_001110853 NM_001110854 NM_001110855 NM_001110856 NM_001110858 NM_001110859 NM_001271504 NM_001271505 NM_001271506 NM_013498 XM_006525555 XM_006525556 XM_006525561 XM_006525563 XM_006525564 XM_006525565 XM_006525566 XM_006525567 XM_006525569 XM_006525573 XM_006525582
OMIM
CCDS CCDS29031 CCDS50209 CCDS50210 CCDS50211 CCDS50212 CCDS50213 CCDS50214 CCDS50215 CCDS70862 CCDS70863 CCDS70864
HPRD
IMGT
MGI ID MGI:88495
MGI Symbol Crem
EMBL AC117589 AY738715 AY738716 AY738717 AY738718 AY738719 AY738721 M60285
GenPept AAA17495 AAA17496 AAA17497 AAV28551 AAV28552 AAV28553 AAV28554 AAV28555 AAV28556
RNA Seq Atlas 12916

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca