InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PPP3R1

Summary

InnateDB Protein

IDBP-54460.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PPP3R1

Protein Name

protein phosphatase 3, regulatory subunit B, alpha

Synonyms

CALNB1; CNB; CNB1;

Species

Homo sapiens

Ensembl Protein

ENSP00000234310

InnateDB Gene

IDBG-281607 (PPP3R1)

Protein Structure

UniProt Annotation

Function

Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity.

Subcellular Localization

Cytoplasm, cytosol {ECO:0000250}. Cell membrane {ECO:0000250}. Cell membrane, sarcolemma. Note=Translocates from the cytosol to the sarcolemma in a CIB1- dependent manner during cardiomyocytes hypertrophy. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	26 [view]
Protein-Protein	25 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004723	calcium-dependent protein serine/threonine phosphatase activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0019904	protein domain specific binding

Biological Process

GO:0001539	cilium or flagellum-dependent cell motility
GO:0001837	epithelial to mesenchymal transition
GO:0006915	apoptotic process
GO:0007507	heart development
GO:0016311	dephosphorylation
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0045087	innate immune response (InnateDB)
GO:0097193	intrinsic apoptotic signaling pathway
GO:1900740	positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway