Version 5.4
Homo sapiens Gene: PPP3R1
Summary
InnateDB Gene IDBG-281607.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PPP3R1
Gene Name protein phosphatase 3, regulatory subunit B, alpha
Synonyms CALNB1; CNB; CNB1
Species Homo sapiens
Ensembl Gene ENSG00000221823
Encoded Proteins
IDBP-54460
protein phosphatase 3, regulatory subunit B, alpha
IDBP-295707
protein phosphatase 3, regulatory subunit B, alpha
IDBP-295712
protein phosphatase 3, regulatory subunit B, alpha
IDBP-295709
protein phosphatase 3, regulatory subunit B, alpha
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 22116828
PPP3R1 plays an important role in activation of peritoneal macrophages. PPP3R1 induces TNFSF10 (TRAIL) gene expression in peritoneal macrophages in an ITGAM-dependent manner. (Demonstrated in mice)
InnateDB Annotation from Orthologs
Summary
PMID 22116828
[Mus musculus] Ppp3r1 plays an important role in activation of peritoneal macrophages. Ppp3r1 induces Tnfsf10 (TRAIL) gene expression in peritoneal macrophages in an Itgam-dependent manner.
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 2:68178857-68256237
Strand Reverse strand
Band p14
Transcripts
ENST00000234310 ENSP00000234310
ENST00000409752 ENSP00000387216
ENST00000406334 ENSP00000384974
ENST00000409377 ENSP00000387148
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 26 [view]
Protein-Protein 25 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004723 calcium-dependent protein serine/threonine phosphatase activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0019904 protein domain specific binding
Biological Process
GO:0006915 apoptotic process
GO:0016311 dephosphorylation
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0045087 innate immune response (InnateDB)
GO:0097193 intrinsic apoptotic signaling pathway
GO:1900740 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
Cellular Component
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0005955 calcineurin complex
GO:0042383 sarcolemma
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000033953
View Gene Order
ENSBTAG00000010619
Not yet available
Pathways
NETPATH
REACTOME
REACT_15334
DARPP-32 events pathway
REACT_15295
Opioid Signalling pathway
REACT_549
Activation of BAD and translocation to mitochondria pathway
REACT_172761
Ca2+ pathway pathway
REACT_172694
beta-catenin independent WNT signaling pathway
REACT_11045
Signaling by Wnt pathway
REACT_14797
Signaling by GPCR pathway
REACT_6802
Innate Immune System pathway
REACT_163936
Fc epsilon receptor (FCERI) signaling pathway
REACT_578
Apoptosis pathway
REACT_111102
Signal Transduction pathway
REACT_697
Activation of BH3-only proteins pathway
REACT_6900
Immune System pathway
REACT_964
Intrinsic Pathway for Apoptosis pathway
REACT_163834
FCERI mediated Ca+2 mobilization pathway
KEGG
hsa04370
VEGF signaling pathway pathway
hsa04310
Wnt signaling pathway pathway
hsa04210
Apoptosis pathway
hsa04010
MAPK signaling pathway pathway
hsa04360
Axon guidance pathway
hsa04720
Long-term potentiation pathway
hsa05010
Alzheimer's disease pathway
hsa04662
B cell receptor signaling pathway pathway
hsa04660
T cell receptor signaling pathway pathway
hsa04650
Natural killer cell mediated cytotoxicity pathway
hsa04020
Calcium signaling pathway pathway
hsa05014
Amyotrophic lateral sclerosis (ALS) pathway
hsa04114
Oocyte meiosis pathway
hsa04380
Osteoclast differentiation pathway
INOH
INOH website
CD4 T cell receptor signaling pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.280604 Hs.697568
RefSeq NM_000945
HUGO
OMIM
CCDS CCDS46310
HPRD 03195
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca