Homo sapiens Protein: NFATC1
InnateDB Protein IDBP-5454.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NFATC1
Protein Name nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
Synonyms NF-ATC; NFAT2; NFATc;
Species Homo sapiens
Ensembl Protein ENSP00000253506
InnateDB Gene IDBG-5452 (NFATC1)
Protein Structure
UniProt Annotation
Function Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 or IL-4 gene transcription. Also controls gene expression in embryonic cardiac cells. Could regulate not only the activation and proliferation but also the differentiation and programmed death of T-lymphocytes as well as lymphoid and non-lymphoid cells.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:16511445}. Nucleus {ECO:0000269PubMed:16511445}. Note=Cytoplasmic for the phosphorylated form and nuclear after activation that is controlled by calcineurin-mediated dephosphorylation. Rapid nuclear exit of NFATC is thought to be one mechanism by which cells distinguish between sustained and transient calcium signals. The subcellular localization of NFATC plays a key role in the regulation of gene transcription.
Disease Associations
Tissue Specificity Expressed in thymus, peripheral leukocytes as T-cells and spleen. Isoforms A are preferentially expressed in effector T-cells (thymus and peripheral leukocytes) whereas isoforms B and isoforms C are preferentially expressed in naive T- cells (spleen). Isoforms B are expressed in naive T-cells after first antigen exposure and isoforms A are expressed in effector T- cells after second antigen exposure. Isoforms IA are widely expressed but not detected in liver nor pancreas, neural expression is strongest in corpus callosum. Isoforms IB are expressed mostly in muscle, cerebellum, placenta and thymus, neural expression in fetal and adult brain, strongest in corpus callosum. {ECO:0000269PubMed:18675896}.
Number of Interactions This gene and/or its encoded proteins are associated with 61 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.
Experimentally validated
Total 61 [view]
Protein-Protein 41 [view]
Protein-DNA 20 [view]
Protein-RNA 0
Predicted by orthology
Total 18 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0001085 RNA polymerase II transcription factor binding
GO:0001205 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003705 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0005528 FK506 binding
GO:0044212 transcription regulatory region DNA binding
GO:0048273 mitogen-activated protein kinase p38 binding
Biological Process
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0035556 intracellular signal transduction
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0045087 innate immune response
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0000790 nuclear chromatin
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
Protein Structure and Domains
InterPro IPR002909 IPT domain
IPR008366 Nuclear factor of activated T cells (NFAT)
IPR008967 p53-like transcription factor, DNA-binding
IPR011539 Rel homology domain
IPR014756 Immunoglobulin E-set
PFAM PF01833
Post-translational Modifications
SwissProt O95644
PhosphoSite PhosphoSite-O95644
UniProt Splice Variant
Entrez Gene 4772
UniGene Hs.739976
RefSeq NP_006153
OMIM 600489
HPRD 02729
EMBL AC018445 AC023090 BC104753 BC112243 CH471117 EU887559 EU887560 EU887561 EU887562 EU887563 EU887564 EU887565 EU887566 U08015 U59736 U80917 U80918 U80919
GenPept AAA19601 AAC50869 AAD00450 AAD00451 AAD00452 AAI04754 AAI12244 ACG55579 ACG55580 ACG55581 ACG55582 ACG55583 ACG55584 ACG55585 ACG55586 EAW66621 EAW66622