Homo sapiens Gene: NFATC1
Summary
InnateDB Gene IDBG-5452.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NFATC1
Gene Name nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
Synonyms NF-ATC; NFAT2; NFATc;
Species Homo sapiens
Ensembl Gene ENSG00000131196
Encoded Proteins
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The product of this gene is a component of the nuclear factor of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation, and an inducible nuclear component. Proteins belonging to this family of transcription factors play a central role in inducible gene transcription during immune response. The product of this gene is an inducible nuclear component. It functions as a major molecular target for the immunosuppressive drugs such as cyclosporin A. Five transcript variants encoding distinct isoforms have been identified for this gene. Different isoforms of this protein may regulate inducible expression of different cytokine genes. [provided by RefSeq, Jul 2008]
The product of this gene is a component of the nuclear factor of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation, and an inducible nuclear component. Proteins belonging to this family of transcription factors play a central role in inducible gene transcription during immune response. The product of this gene is an inducible nuclear component. It functions as a major molecular target for the immunosuppressive drugs such as cyclosporin A. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Different isoforms of this protein may regulate inducible expression of different cytokine genes. [provided by RefSeq, Jul 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:79395856-79529325
Strand Forward strand
Band q23
Transcripts
ENST00000253506 ENSP00000253506
ENST00000318065 ENSP00000316553
ENST00000329101 ENSP00000327850
ENST00000397790 ENSP00000380892
ENST00000427363 ENSP00000389377
ENST00000542384 ENSP00000442435
ENST00000545796 ENSP00000439992
ENST00000590224
ENST00000591089
ENST00000586695
ENST00000590172
ENST00000590313 ENSP00000467615
ENST00000586434 ENSP00000466489
ENST00000591814 ENSP00000466194
ENST00000591065
ENST00000592223 ENSP00000467181
ENST00000590861
ENST00000587635 ENSP00000468111
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 61 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.
Experimentally validated
Total 61 [view]
Protein-Protein 41 [view]
Protein-DNA 20 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 18 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding
GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0001085 RNA polymerase II transcription factor binding
GO:0001205 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003705 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0005528 FK506 binding
GO:0043565 sequence-specific DNA binding
GO:0044212 transcription regulatory region DNA binding
GO:0048273 mitogen-activated protein kinase p38 binding
Biological Process
GO:0000082 G1/S transition of mitotic cell cycle
GO:0001837 epithelial to mesenchymal transition
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0006816 calcium ion transport
GO:0007507 heart development
GO:0010628 positive regulation of gene expression
GO:0030316 osteoclast differentiation
GO:0035556 intracellular signal transduction
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0045087 innate immune response
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0000790 nuclear chromatin
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription factor complex
GO:0005737 cytoplasm
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
TCR pathway
RANKL pathway
REACTOME
Ca2+ pathway pathway
beta-catenin independent WNT signaling pathway
Signaling by Wnt pathway
Innate Immune System pathway
Fc epsilon receptor (FCERI) signaling pathway
Signal Transduction pathway
Immune System pathway
FCERI mediated Ca+2 mobilization pathway
KEGG
MAPK signaling pathway pathway
Wnt signaling pathway pathway
Osteoclast differentiation pathway
Natural killer cell mediated cytotoxicity pathway
T cell receptor signaling pathway pathway
B cell receptor signaling pathway pathway
INOH
PID BIOCARTA
Signaling pathway from g-protein families [Biocarta view]
Bcr signaling pathway [Biocarta view]
Effects of calcineurin in keratinocyte differentiation [Biocarta view]
Nfat and hypertrophy of the heart [Biocarta view]
Gata3 participate in activating the th2 cytokine genes expression [Biocarta view]
Role of mef2d in t-cell apoptosis [Biocarta view]
Control of skeletal myogenesis by hdac and calcium/calmodulin-dependent kinase (camk) [Biocarta view]
Fmlp induced chemokine gene expression in hmc-1 cells [Biocarta view]
T cell receptor signaling pathway [Biocarta view]
PID NCI
Downstream signaling in na´ve CD8+ T cells
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
Glucocorticoid receptor regulatory network
BCR signaling pathway
Role of Calcineurin-dependent NFAT signaling in lymphocytes
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.534074 Hs.739976
RefSeq NM_001278669 NM_001278670 NM_001278672 NM_001278673 NM_001278675 NM_006162 NM_172387 NM_172388 NM_172389 NM_172390 XM_006722477 XM_006722478
HUGO
OMIM
CCDS CCDS12015 CCDS12016 CCDS32850 CCDS59326 CCDS59327 CCDS62467 CCDS62468 CCDS62469 CCDS62470 CCDS62471
HPRD 02729
IMGT
EMBL
GenPept
RNA Seq Atlas