InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PLEK

Summary

InnateDB Protein

IDBP-54588.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PLEK

Protein Name

pleckstrin

Synonyms

P47;

Species

Homo sapiens

Ensembl Protein

ENSP00000234313

InnateDB Gene

IDBG-54586 (PLEK)

Protein Structure

UniProt Annotation

Function

Major protein kinase C substrate of platelets.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005080	protein kinase C binding
GO:0005515	protein binding
GO:0042803	protein homodimerization activity
GO:0043325	phosphatidylinositol-3,4-bisphosphate binding

Biological Process

GO:0002244	hematopoietic progenitor cell differentiation
GO:0002576	platelet degranulation
GO:0006904	vesicle docking involved in exocytosis
GO:0007229	integrin-mediated signaling pathway
GO:0007596	blood coagulation
GO:0010572	positive regulation of platelet activation
GO:0010920	negative regulation of inositol phosphate biosynthetic process
GO:0010925	positive regulation of inositol-polyphosphate 5-phosphatase activity
GO:0030030	cell projection organization
GO:0030168	platelet activation
GO:0030836	positive regulation of actin filament depolymerization
GO:0030845	phospholipase C-inhibiting G-protein coupled receptor signaling pathway
GO:0030866	cortical actin cytoskeleton organization
GO:0031529	ruffle organization
GO:0031532	actin cytoskeleton reorganization
GO:0032233	positive regulation of actin filament bundle assembly
GO:0033625	positive regulation of integrin activation
GO:0035556	intracellular signal transduction
GO:0045744	negative regulation of G-protein coupled receptor protein signaling pathway
GO:0046488	phosphatidylinositol metabolic process
GO:0050849	negative regulation of calcium-mediated signaling
GO:0060305	regulation of cell diameter
GO:0070493	thrombin receptor signaling pathway
GO:0070527	platelet aggregation
GO:0070528	protein kinase C signaling
GO:0070560	protein secretion by platelet