Version 5.4
Homo sapiens Gene: PLEK
Summary
InnateDB Gene IDBG-54586.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PLEK
Gene Name pleckstrin
Synonyms P47
Species Homo sapiens
Ensembl Gene ENSG00000115956
Encoded Proteins
IDBP-54588
pleckstrin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 2:68365173-68397453
Strand Forward strand
Band p14
Transcripts
ENST00000234313 ENSP00000234313
ENST00000474788
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005080 protein kinase C binding
GO:0005515 protein binding
GO:0042803 protein homodimerization activity
GO:0043325 phosphatidylinositol-3,4-bisphosphate binding
Biological Process
GO:0002244 hematopoietic progenitor cell differentiation
GO:0002576 platelet degranulation
GO:0006904 vesicle docking involved in exocytosis
GO:0007229 integrin-mediated signaling pathway
GO:0007596 blood coagulation
GO:0010572 positive regulation of platelet activation
GO:0010920 negative regulation of inositol phosphate biosynthetic process
GO:0010925 positive regulation of inositol-polyphosphate 5-phosphatase activity
GO:0030030 cell projection organization
GO:0030168 platelet activation
GO:0030836 positive regulation of actin filament depolymerization
GO:0030845 phospholipase C-inhibiting G-protein coupled receptor signaling pathway
GO:0030866 cortical actin cytoskeleton organization
GO:0031529 ruffle organization
GO:0031532 actin cytoskeleton reorganization
GO:0032233 positive regulation of actin filament bundle assembly
GO:0033625 positive regulation of integrin activation
GO:0035556 intracellular signal transduction
GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway
GO:0046488 phosphatidylinositol metabolic process
GO:0050849 negative regulation of calcium-mediated signaling
GO:0060305 regulation of cell diameter
GO:0070493 thrombin receptor signaling pathway
GO:0070527 platelet aggregation
GO:0070528 protein kinase C signaling
GO:0070560 protein secretion by platelet
Cellular Component
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016020 membrane
GO:0032587 ruffle membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020120
View Gene Order
ENSBTAG00000009658
Not yet available
Pathways
NETPATH
REACTOME
REACT_318
Platelet degranulation pathway
REACT_1280
Response to elevated platelet cytosolic Ca2+ pathway
REACT_798
Platelet activation, signaling and aggregation pathway
REACT_604
Hemostasis pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.468840
RefSeq NM_002664
HUGO
OMIM
CCDS CCDS1887
HPRD 15935
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca