Version 5.4
Homo sapiens Protein: PODXL2
Summary
InnateDB Protein IDBP-54939.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PODXL2
Protein Name podocalyxin-like 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000345359
InnateDB Gene IDBG-54937 (PODXL2)
Protein Structure
UniProt Annotation
Function Acts as a ligand for vascular selectins. Mediates rapid rolling of leukocytes over vascular surfaces through high affinity divalent cation-dependent interactions with E-, P- and L- selectins. {ECO:0000269PubMed:18606703}.
Subcellular Localization Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity Expressed in T-cells, B-cells and monocytes. Expression is higher on memory and germinal center cells than on naive B-cells (at protein level). Highly expressed in brain. Moderately expressed in pancreas, kidney and lymphoid node. Weakly expressed in liver. Detected in both endothelial cells and CD34+ bone marrow cells. {ECO:0000269PubMed:10722749, ECO:0000269PubMed:18606703}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005539 glycosaminoglycan binding
Biological Process
GO:0050901 leukocyte tethering or rolling
Cellular Component
GO:0005887 integral component of plasma membrane
Protein Structure and Domains
PDB ID
InterPro IPR013836 CD34/Podocalyxin
PFAM PF06365
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9NZ53
PhosphoSite PhosphoSite-Q9NZ53
TrEMBL
UniProt Splice Variant
Entrez Gene 50512
UniGene Hs.591290
RefSeq NP_056535
HUGO HGNC:17936
OMIM
CCDS CCDS3044
HPRD 15154
IMGT
EMBL AF219137 AY359096 BC019330 BC052585
GenPept AAF44629 AAH19330 AAH52585 AAQ89454

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca