InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SEC61A1

Summary

InnateDB Protein

IDBP-55074.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SEC61A1

Protein Name

Sec61 alpha 1 subunit (S. cerevisiae)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000243253

InnateDB Gene

IDBG-55072 (SEC61A1)

Protein Structure

UniProt Annotation

Function

Plays a crucial role in the insertion of secretory and membrane polypeptides into the ER. Required for assembly of membrane and secretory proteins. Tightly associated with membrane- bound ribosomes, either directly or through adapter proteins.

Subcellular Localization

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 35 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	35 [view]
Protein-Protein	35 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0043022	ribosome binding

Biological Process

GO:0002474	antigen processing and presentation of peptide antigen via MHC class I
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0006614	SRP-dependent cotranslational protein targeting to membrane
GO:0006620	posttranslational protein targeting to membrane
GO:0007029	endoplasmic reticulum organization
GO:0015031	protein transport
GO:0016049	cell growth
GO:0034341	response to interferon-gamma
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I
GO:0045047	protein targeting to ER