InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RPN1

Summary

InnateDB Protein

IDBP-55264.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RPN1

Protein Name

ribophorin I

Synonyms

OST1; RBPH1;

Species

Homo sapiens

Ensembl Protein

ENSP00000296255

InnateDB Gene

IDBG-55262 (RPN1)

Protein Structure

UniProt Annotation

Function

Essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains.

Subcellular Localization

Endoplasmic reticulum membrane; Single-pass type I membrane protein. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Disease Associations

Tissue Specificity

Expressed in all tissues tested. {ECO:0000269PubMed:12887896}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 63 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	63 [view]
Protein-Protein	61 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004579	dolichyl-diphosphooligosaccharide-protein glycotransferase activity
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006412	translation
GO:0006464	cellular protein modification process
GO:0006486	protein glycosylation
GO:0006614	SRP-dependent cotranslational protein targeting to membrane
GO:0010467	gene expression
GO:0018279	protein N-linked glycosylation via asparagine
GO:0043687	post-translational protein modification
GO:0044267	cellular protein metabolic process

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005791	rough endoplasmic reticulum
GO:0008250	oligosaccharyltransferase complex
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0042470	melanosome