Homo sapiens Gene: RPN1
Summary
InnateDB Gene IDBG-55262.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RPN1
Gene Name ribophorin I
Synonyms OST1; RBPH1;
Species Homo sapiens
Ensembl Gene ENSG00000163902
Encoded Proteins
ribophorin I
ribophorin I
ribophorin I
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a type I integral membrane protein found only in the rough endoplasmic reticulum. The encoded protein is part of an N-oligosaccharyl transferase complex that links high mannose oligosaccharides to asparagine residues found in the Asn-X-Ser/Thr consensus motif of nascent polypeptide chains. This protein forms part of the regulatory subunit of the 26S proteasome and may mediate binding of ubiquitin-like domains to this proteasome. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:128619970-128681075
Strand Reverse strand
Band q21.3
Transcripts
ENST00000296255 ENSP00000296255
ENST00000497289 ENSP00000417529
ENST00000490166
ENST00000495462
ENST00000479113
ENST00000476931 ENSP00000419384
ENST00000497415
ENST00000481168
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 63 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 63 [view]
Protein-Protein 61 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006412 translation
GO:0006464 cellular protein modification process
GO:0006486 protein glycosylation
GO:0006614 SRP-dependent cotranslational protein targeting to membrane
GO:0010467 gene expression
GO:0018279 protein N-linked glycosylation via asparagine
GO:0043687 post-translational protein modification
GO:0044267 cellular protein metabolic process
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005791 rough endoplasmic reticulum
GO:0008250 oligosaccharyltransferase complex
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0042470 melanosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
SRP-dependent cotranslational protein targeting to membrane pathway
Post-translational protein modification pathway
Translation pathway
Asparagine N-linked glycosylation pathway
Metabolism of proteins pathway
Gene Expression pathway
KEGG
N-Glycan biosynthesis pathway
Protein processing in endoplasmic reticulum pathway
INOH
PID BIOCARTA
Proteasome complex [Biocarta view]
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.518244 Hs.734783
RefSeq NM_002950
HUGO
OMIM
CCDS CCDS3051
HPRD 01598
IMGT
EMBL
GenPept
RNA Seq Atlas