InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SELPLG

Summary

InnateDB Protein

IDBP-55473.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SELPLG

Protein Name

selectin P ligand

Synonyms

CD162; CLA; PSGL-1; PSGL1;

Species

Homo sapiens

Ensembl Protein

ENSP00000373614

InnateDB Gene

IDBG-55469 (SELPLG)

Protein Structure

UniProt Annotation

Function

A SLe(x)-type proteoglycan, which through high affinity, calcium-dependent interactions with E-, P- and L-selectins, mediates rapid rolling of leukocytes over vascular surfaces during the initial steps in inflammation. Critical for the initial leukocyte capture. {ECO:0000269PubMed:11566773, ECO:0000269PubMed:12403782}.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Expressed on neutrophils, monocytes and most lymphocytes.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	19 [view]
Protein-Protein	19 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005515	protein binding

Biological Process

GO:0007155	cell adhesion
GO:0007596	blood coagulation
GO:0050900	leukocyte migration
GO:0050902	leukocyte adhesive activation
GO:0071354	cellular response to interleukin-6