Homo sapiens Gene: SELPLG
Summary
InnateDB Gene IDBG-55469.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SELPLG
Gene Name selectin P ligand
Synonyms CD162; CLA; PSGL-1; PSGL1;
Species Homo sapiens
Ensembl Gene ENSG00000110876
Encoded Proteins
selectin P ligand
selectin P ligand
selectin P ligand
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a glycoprotein that functions as a high affinity counter-receptor for the cell adhesion molecules P-, E- and L- selectin expressed on myeloid cells and stimulated T lymphocytes. As such, this protein plays a critical role in leukocyte trafficking during inflammation by tethering of leukocytes to activated platelets or endothelia expressing selectins. This protein requires two post-translational modifications, tyrosine sulfation and the addition of the sialyl Lewis x tetrasaccharide (sLex) to its O-linked glycans, for its high-affinity binding activity. Aberrant expression of this gene and polymorphisms in this gene are associated with defects in the innate and adaptive immune response. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:108622277-108633959
Strand Reverse strand
Band q24.11
Transcripts
ENST00000228463 ENSP00000228463
ENST00000388962 ENSP00000373614
ENST00000550948 ENSP00000447752
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 19 [view]
Protein-Protein 19 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005515 protein binding
Biological Process
GO:0007155 cell adhesion
GO:0007596 blood coagulation
GO:0050900 leukocyte migration
GO:0050901 leukocyte tethering or rolling
GO:0050902 leukocyte adhesive activation
GO:0071354 cellular response to interleukin-6
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Cell surface interactions at the vascular wall pathway
Hemostasis pathway
KEGG
Cell adhesion molecules (CAMs) pathway
Staphylococcus aureus infection pathway
INOH
PID BIOCARTA
PID NCI
amb2 Integrin signaling
Cross-References
SwissProt Q14242
TrEMBL
UniProt Splice Variant
Entrez Gene 6404
UniGene Hs.591014
RefSeq NM_001206609 NM_003006
HUGO HGNC:10722
OMIM 600738
CCDS CCDS55881 CCDS31895
HPRD 02845
IMGT
EMBL AC007569 AC008119 AK098315 AK290395 AK298738 AK298742 AY331789 BC029782 U02297 U25956
GenPept AAA74577 AAC50061 AAH29782 AAP81163 BAC05283 BAF83084 BAG60885 BAH12863
RNA Seq Atlas 6404