Version 5.4
Homo sapiens Protein: FKBP3
Summary
InnateDB Protein IDBP-5579.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FKBP3
Protein Name FK506 binding protein 3, 25kDa
Synonyms FKBP-25; FKBP-3; FKBP25; PPIase;
Species Homo sapiens
Ensembl Protein ENSP00000216330
InnateDB Gene IDBG-5577 (FKBP3)
Protein Structure
UniProt Annotation
Function FK506- and rapamycin-binding proteins (FKBPs) constitute a family of receptors for the two immunosuppressants which inhibit T-cell proliferation by arresting two distinct cytoplasmic signal transmission pathways. PPIases accelerate the folding of proteins.
Subcellular Localization Nucleus.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 44 experimentally validated interaction(s) in this database.
Experimentally validated
Total 44 [view]
Protein-Protein 43 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003755 peptidyl-prolyl cis-trans isomerase activity
GO:0004872 receptor activity
GO:0005515 protein binding
GO:0005528 FK506 binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000413 protein peptidyl-prolyl isomerization
GO:0006457 protein folding
GO:0061077 chaperone-mediated protein folding
Cellular Component
GO:0005634 nucleus
GO:0005789 endoplasmic reticulum membrane
Protein Structure and Domains
PDB ID
InterPro IPR001179 Peptidyl-prolyl cis-trans isomerase, FKBP-type, domain
IPR013750 GHMP kinase, C-terminal domain
PFAM PF00254
PF08544
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q00688
PhosphoSite PhosphoSite-Q00688
TrEMBL
UniProt Splice Variant
Entrez Gene 2287
UniGene
RefSeq
HUGO HGNC:3719
OMIM 186947
CCDS CCDS9683
HPRD 01743
IMGT
EMBL AK311915 BC016288 BC020809 BT006904 CH471078 M90309 M90820 M96256
GenPept AAA58471 AAA58474 AAA58475 AAH16288 AAH20809 AAP35550 BAG34856 EAW65785

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca