Version 5.4
Homo sapiens Gene: FKBP3
Summary
InnateDB Gene IDBG-5577.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FKBP3
Gene Name FK506 binding protein 3, 25kDa
Synonyms FKBP-25; FKBP-3; FKBP25; PPIase
Species Homo sapiens
Ensembl Gene ENSG00000100442
Encoded Proteins
IDBP-5579
FK506 binding protein 3, 25kDa
IDBP-238278
FK506 binding protein 3, 25kDa
IDBP-595528
FK506 binding protein 3, 25kDa
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin, as well as histone deacetylases, the transcription factor YY1, casein kinase II, and nucleolin. It has a higher affinity for rapamycin than for FK506 and thus may be an important target molecule for immunosuppression by rapamycin. [provided by RefSeq, Sep 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:45115600-45135319
Strand Reverse strand
Band q21.2
Transcripts
ENST00000216330 ENSP00000216330
ENST00000396062 ENSP00000379374
ENST00000557324 ENSP00000452322
ENST00000556231
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 44 experimentally validated interaction(s) in this database.
Experimentally validated
Total 44 [view]
Protein-Protein 43 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003755 peptidyl-prolyl cis-trans isomerase activity
GO:0004872 receptor activity
GO:0005515 protein binding
GO:0005528 FK506 binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000413 protein peptidyl-prolyl isomerization
GO:0006457 protein folding
GO:0061077 chaperone-mediated protein folding
Cellular Component
GO:0005634 nucleus
GO:0005789 endoplasmic reticulum membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020949
View Gene Order
ENSBTAG00000002610
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
hdac_classi_pathway
Signaling events mediated by HDAC Class I
Cross-References
SwissProt
TrEMBL G3V5F2
UniProt Splice Variant
Entrez Gene 2287
UniGene
RefSeq NM_002013
HUGO HGNC:3719
OMIM 186947
CCDS CCDS9683
HPRD 01743
IMGT
EMBL AL121809
GenPept
RNA Seq Atlas 2287

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca