InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ITGB2

Summary

InnateDB Protein

IDBP-5594.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ITGB2

Protein Name

integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)

Synonyms

CD18; LAD; LCAMB; LFA-1; MAC-1; MF17; MFI7;

Species

Homo sapiens

Ensembl Protein

ENSP00000303242

InnateDB Gene

IDBG-5590 (ITGB2)

Protein Structure

UniProt Annotation

Function

Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrins alpha-M/beta-2 and alpha-X/beta-2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin alpha-X/beta-2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin alpha-M/beta-2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin alpha-M/beta-2 is also a receptor for factor X. Integrin alpha- D/beta-2 is a receptor for ICAM3 and VCAM1. Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation. {ECO:0000269PubMed:18587400}.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Leukocyte adhesion deficiency 1 (LAD1) [MIM:116920]: LAD1 patients have recurrent bacterial infections and their leukocytes are deficient in a wide range of adhesion-dependent functions. {ECO:0000269PubMed:1346613, ECO:0000269PubMed:1347532, ECO:0000269PubMed:1352501, ECO:0000269PubMed:1590804, ECO:0000269PubMed:1694220, ECO:0000269PubMed:1968911, ECO:0000269PubMed:20529581, ECO:0000269PubMed:20549317, ECO:0000269PubMed:7509236, ECO:0000269PubMed:7686755, ECO:0000269PubMed:9884339}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 66 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	66 [view]
Protein-Protein	66 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001948	glycoprotein binding
GO:0004872	receptor activity
GO:0005515	protein binding
GO:0019901	protein kinase binding
GO:0046872	metal ion binding

Biological Process

GO:0002224	toll-like receptor signaling pathway
GO:0006915	apoptotic process
GO:0006954	inflammatory response
GO:0007155	cell adhesion
GO:0007159	leukocyte cell-cell adhesion
GO:0007160	cell-matrix adhesion
GO:0007229	integrin-mediated signaling pathway
GO:0007267	cell-cell signaling
GO:0007275	multicellular organismal development
GO:0007596	blood coagulation
GO:0008360	regulation of cell shape
GO:0030198	extracellular matrix organization
GO:0030593	neutrophil chemotaxis
GO:0034142	toll-like receptor 4 signaling pathway
GO:0045087	innate immune response (InnateDB)
GO:0050730	regulation of peptidyl-tyrosine phosphorylation
GO:0050776	regulation of immune response
GO:0050900	leukocyte migration

Cellular Component

GO:0005886	plasma membrane
GO:0008305	integrin complex
GO:0009986	cell surface
GO:0016020	membrane
GO:0043235	receptor complex
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR002035 von Willebrand factor, type A
IPR002369 Integrin beta subunit, N-terminal
IPR012896 Integrin beta subunit, tail
IPR013111 EGF-like domain, extracellular
IPR014836 Integrin beta subunit, cytoplasmic domain
IPR015812 Integrin beta subunit
IPR016201 Plexin-like fold

PFAM

PF00092
PF00362
PF07965
PF07974
PF08725

PRINTS

PR01186

PIRSF

PIRSF002512

SMART

SM00327
SM00187
SM00423

TIGRFAMs

Post-translational Modifications

Modification

Cross-References