Version 5.4
Homo sapiens Protein: ITGB2
Summary
InnateDB Protein IDBP-5596.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ITGB2
Protein Name integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
Synonyms CD18; LAD; LCAMB; LFA-1; MAC-1; MF17; MFI7;
Species Homo sapiens
Ensembl Protein ENSP00000317697
InnateDB Gene IDBG-5590 (ITGB2)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 66 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 66 [view]
Protein-Protein 66 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
Biological Process
GO:0007160 cell-matrix adhesion
GO:0007229 integrin-mediated signaling pathway
GO:0007275 multicellular organismal development
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0008305 integrin complex
GO:0016020 membrane
Protein Structure and Domains
PDB ID
InterPro IPR002035 von Willebrand factor, type A
IPR002369 Integrin beta subunit, N-terminal
IPR015812 Integrin beta subunit
IPR016201 Plexin-like fold
PFAM PF00092
PF00362
PRINTS PR01186
PIRSF PIRSF002512
SMART SM00327
SM00187
SM00423
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL Q96PT7
UniProt Splice Variant
Entrez Gene 3689
UniGene Hs.375957
RefSeq
HUGO HGNC:6155
OMIM 600065
CCDS
HPRD 02506
IMGT
EMBL AF016894 AL773603 AL844907 AL844908 KJ528565 KJ528566 KJ528568 KJ528569 KJ528573 KJ528574 KJ528575 KJ528576 KJ528578
GenPept AAL14027 AHZ44417 AHZ44418 AHZ44420 AHZ44421 AHZ44424 AHZ44425 AHZ44426 AHZ44427 AHZ44428

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca