InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: KPNB1

Summary

InnateDB Protein

IDBP-56055.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KPNB1

Protein Name

karyopherin (importin) beta 1

Synonyms

IMB1; Impnb; IPO1; IPOB; NTF97;

Species

Homo sapiens

Ensembl Protein

ENSP00000290158

InnateDB Gene

IDBG-56053 (KPNB1)

Protein Structure

UniProt Annotation

Function

Functions in nuclear protein import, either in association with an adapter protein, like an importin-alpha subunit, which binds to nuclear localization signals (NLS) in cargo substrates, or by acting as autonomous nuclear transport receptor. Acting autonomously, serves itself as NLS receptor. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re- exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates autonomously the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In association with IPO7 mediates the nuclear import of H1 histone. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev. Imports SNAI1 and PRKCI into the nucleus. {ECO:0000269PubMed:10228156, ECO:0000269PubMed:11891849, ECO:0000269PubMed:19386897, ECO:0000269PubMed:9687515}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:11891849}. Nucleus envelope {ECO:0000269PubMed:11891849}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 182 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	182 [view]
Protein-Protein	179 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005488	binding
GO:0005515	protein binding
GO:0008139	nuclear localization sequence binding
GO:0008270	zinc ion binding
GO:0008536	Ran GTPase binding
GO:0008565	protein transporter activity
GO:0019899	enzyme binding
GO:0019904	protein domain specific binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000060	protein import into nucleus, translocation
GO:0006309	apoptotic DNA fragmentation
GO:0006606	protein import into nucleus
GO:0006607	NLS-bearing protein import into nucleus
GO:0006610	ribosomal protein import into nucleus
GO:0006886	intracellular protein transport
GO:0006915	apoptotic process
GO:0006921	cellular component disassembly involved in execution phase of apoptosis
GO:0016032	viral process
GO:0019058	viral life cycle
GO:0019221	cytokine-mediated signaling pathway
GO:0044281	small molecule metabolic process
GO:0075733	intracellular transport of virus

Cellular Component

GO:0005634	nucleus
GO:0005635	nuclear envelope
GO:0005643	nuclear pore
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0016020	membrane
GO:0031965	nuclear membrane
GO:0043234	protein complex
GO:0070062	extracellular vesicular exosome
GO:0071782	endoplasmic reticulum tubular network