InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PLXND1

Summary

InnateDB Protein

IDBP-56136.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PLXND1

Protein Name

plexin D1

Synonyms

PLEXD1;

Species

Homo sapiens

Ensembl Protein

ENSP00000317128

InnateDB Gene

IDBG-56134 (PLXND1)

Protein Structure

UniProt Annotation

Function

Cell surface receptor for SEMA4A and for class 3 semaphorins, such as SEMA3A, SEMA3C and SEMA3E. Plays an important role in cell-cell signaling, and in regulating the migration of a wide spectrum of cell types. Regulates the migration of thymocytes in the medulla. Regulates endothelial cell migration. Plays an important role in ensuring the specificity of synapse formation. Required for normal development of the heart and vasculature (By similarity). Mediates anti-angiogenic signaling in response to SEMA3E. {ECO:0000250, ECO:0000269PubMed:20385769}.

Subcellular Localization

Cell membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Detected at low levels in heart, placenta, lung, skeletal muscle, kidney, thymus and liver. Detected at very low levels in brain, colon, spleen, small intestine and peripheral blood leukocytes. {ECO:0000269PubMed:12412018}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0005515	protein binding
GO:0017154	semaphorin receptor activity
GO:0019904	protein domain specific binding

Biological Process

GO:0001525	angiogenesis
GO:0001569	patterning of blood vessels
GO:0003151	outflow tract morphogenesis
GO:0007165	signal transduction
GO:0007275	multicellular organismal development
GO:0007411	axon guidance
GO:0007416	synapse assembly
GO:0030334	regulation of cell migration
GO:0032092	positive regulation of protein binding
GO:0043542	endothelial cell migration
GO:0045765	regulation of angiogenesis
GO:0060666	dichotomous subdivision of terminal units involved in salivary gland branching
GO:0071526	semaphorin-plexin signaling pathway

Cellular Component

GO:0005622	intracellular
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0030027	lamellipodium

Protein Structure and Domains

PDB ID

InterPro

IPR001627 Sema domain
IPR002165 Plexin
IPR002909 IPT domain
IPR008936 Rho GTPase activation protein
IPR013548 Plexin, cytoplasmic RasGAP domain
IPR014756 Immunoglobulin E-set
IPR016201 Plexin-like fold

PFAM

PF01403
PF01437
PF01833
PF08337

PRINTS

PIRSF

SMART

SM00630
SM00429
SM00423

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9Y4D7