Version 5.4
Homo sapiens Protein: TBX21
Summary
InnateDB Protein IDBP-56153.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TBX21
Protein Name T-box 21
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000177694
InnateDB Gene IDBG-56151 (TBX21)
Protein Structure
UniProt Annotation
Function Transcription factor that controls the expression of the TH1 cytokine, interferon-gamma. Initiates TH1 lineage development from naive TH precursor cells both by activating TH1 genetic programs and by repressing the opposing TH2 programs.
Subcellular Localization Nucleus.
Disease Associations Asthma, with nasal polyps and aspirin intolerance (ANPAI) [MIM:208550]: A condition consisting of asthma, aspirin sensitivity and nasal polyposis. Nasal polyposis is due to chronic inflammation of the paranasal sinus mucosa, leading to protrusion of edematous polyps into the nasal cavities. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
Tissue Specificity T-cell specific.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 47 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.
Experimentally validated
Total 47 [view]
Protein-Protein 9 [view]
Protein-DNA 38 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 18 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0044212 transcription regulatory region DNA binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007275 multicellular organismal development
GO:0009615 response to virus
GO:0030217 T cell differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0048304 positive regulation of isotype switching to IgG isotypes
GO:0050776 regulation of immune response
GO:0071310 cellular response to organic substance
GO:0072676 lymphocyte migration
Cellular Component
GO:0005634 nucleus
GO:0043025 neuronal cell body
Protein Structure and Domains
PDB ID
InterPro IPR001699 Transcription factor, T-box
IPR008967 p53-like transcription factor, DNA-binding
PFAM PF00907
PRINTS PR00937
PIRSF
SMART SM00425
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9UL17
PhosphoSite PhosphoSite-Q9UL17
TrEMBL
UniProt Splice Variant
Entrez Gene 30009
UniGene Hs.272409
RefSeq NP_037483
HUGO HGNC:11599
OMIM 604895
CCDS CCDS11514
HPRD 05355
IMGT
EMBL AF093098 AF241243 BC039739
GenPept AAF00055 AAF61243 AAH39739

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca