|Homo sapiens Gene: TBX21|
|Last Modified||2014-10-13 [Report errors or provide feedback]|
|Gene Name||T-box 21|
|Useful resources||Stemformatics EHFPI ImmGen|
|InnateDB Annotation from Orthologs|
[Mus musculus] Tbx21 (T-bet) is a member of the T-box transcription factor family that plays a critical role in interferon (IFN)-gamma regulation and promotion of cell-mediated immune responses against intracellular pathogens.
[Mus musculus] Tbx21 (T-bet) regulates the interplay between mucosal dendritic cells, innate lymphoid cells, and the intestinal microbiota.
[Mus musculus] Gradual expression of Tbx21 controls the fate and function of innate lymphoid cells.
This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is the human ortholog of mouse Tbx21/Tbet gene. Studies in mouse show that Tbx21 protein is a Th1 cell-specific transcription factor that controls the expression of the hallmark Th1 cytokine, interferon-gamma (IFNG). Expression of the human ortholog also correlates with IFNG expression in Th1 and natural killer cells, suggesting a role for this gene in initiating Th1 lineage development from naive Th precursor cells. [provided by RefSeq, Jul 2008]
|Genomic Location||Chromosome 17:47733244-47746119|
|Number of Interactions||
This gene and/or its encoded proteins are associated with 47 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.
IL27-mediated signaling events
IL12-mediated signaling events
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
IL12 signaling mediated by STAT4
Glucocorticoid receptor regulatory network
|UniProt Splice Variant|
|RNA Seq Atlas|