InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: TBX21

Summary

InnateDB Gene

IDBG-56151.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TBX21

Gene Name

T-box 21

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000073861

Encoded Proteins

IDBP-56153

T-box 21

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 11752460

[Mus musculus] Tbx21 (T-bet) is a member of the T-box transcription factor family that plays a critical role in interferon (IFN)-gamma regulation and promotion of cell-mediated immune responses against intracellular pathogens.

PMID 23063332

[Mus musculus] Tbx21 (T-bet) regulates the interplay between mucosal dendritic cells, innate lymphoid cells, and the intestinal microbiota.

PMID 23334414

[Mus musculus] Gradual expression of Tbx21 controls the fate and function of innate lymphoid cells.

Entrez Gene

Summary

This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is the human ortholog of mouse Tbx21/Tbet gene. Studies in mouse show that Tbx21 protein is a Th1 cell-specific transcription factor that controls the expression of the hallmark Th1 cytokine, interferon-gamma (IFNG). Expression of the human ortholog also correlates with IFNG expression in Th1 and natural killer cells, suggesting a role for this gene in initiating Th1 lineage development from naive Th precursor cells. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:47733244-47746119

Strand

Forward strand

Band

q21.32

Transcripts

ENST00000177694	ENSP00000177694
ENST00000581328

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 47 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.

Experimentally validated
Total	47 [view]
Protein-Protein	9 [view]
Protein-DNA	38 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	18 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0044212	transcription regulatory region DNA binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007275	multicellular organismal development
GO:0009615	response to virus
GO:0030217	T cell differentiation
GO:0045893	positive regulation of transcription, DNA-templated
GO:0048304	positive regulation of isotype switching to IgG isotypes
GO:0050776	regulation of immune response
GO:0071310	cellular response to organic substance
GO:0072676	lymphocyte migration

Cellular Component

GO:0005634	nucleus
GO:0043025	neuronal cell body

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

Method

Confidence

Comments

ENSMUSG00000001444

View Gene Order

Ortholuge

SSD Ortholog

Ortholog supports species divergence

ENSBTAG00000014199

Not yet available

Ortholuge

SSD Ortholog

Ortholog supports species divergence

Pathways

NETPATH

REACTOME

KEGG

INOH

PID BIOCARTA

PID NCI

il27pathway

IL27-mediated signaling events

il12_2pathway

IL12-mediated signaling events

nfat_tfpathway

Calcineurin-regulated NFAT-dependent transcription in lymphocytes

il12_stat4pathway

IL12 signaling mediated by STAT4

reg_gr_pathway

Glucocorticoid receptor regulatory network

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.272409

RefSeq

NM_013351

HUGO

OMIM

CCDS

CCDS11514

HPRD

05355

IMGT

EMBL

GenPept

RNA Seq Atlas