Homo sapiens Gene: TBX21
Summary
InnateDB Gene IDBG-56151.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TBX21
Gene Name T-box 21
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000073861
Encoded Proteins
T-box 21
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
[Mus musculus] Tbx21 (T-bet) is a member of the T-box transcription factor family that plays a critical role in interferon (IFN)-gamma regulation and promotion of cell-mediated immune responses against intracellular pathogens.
[Mus musculus] Tbx21 (T-bet) regulates the interplay between mucosal dendritic cells, innate lymphoid cells, and the intestinal microbiota.
[Mus musculus] Gradual expression of Tbx21 controls the fate and function of innate lymphoid cells.
Entrez Gene
Summary This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is the human ortholog of mouse Tbx21/Tbet gene. Studies in mouse show that Tbx21 protein is a Th1 cell-specific transcription factor that controls the expression of the hallmark Th1 cytokine, interferon-gamma (IFNG). Expression of the human ortholog also correlates with IFNG expression in Th1 and natural killer cells, suggesting a role for this gene in initiating Th1 lineage development from naive Th precursor cells. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:47733244-47746119
Strand Forward strand
Band q21.32
Transcripts
ENST00000177694 ENSP00000177694
ENST00000581328
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 47 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.
Experimentally validated
Total 47 [view]
Protein-Protein 9 [view]
Protein-DNA 38 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 18 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0044212 transcription regulatory region DNA binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007275 multicellular organismal development
GO:0009615 response to virus
GO:0030217 T cell differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0048304 positive regulation of isotype switching to IgG isotypes
GO:0050776 regulation of immune response
GO:0071310 cellular response to organic substance
GO:0072676 lymphocyte migration
Cellular Component
GO:0005634 nucleus
GO:0043025 neuronal cell body
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
INOH
PID BIOCARTA
PID NCI
IL27-mediated signaling events
IL12-mediated signaling events
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
IL12 signaling mediated by STAT4
Glucocorticoid receptor regulatory network
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.272409
RefSeq NM_013351
HUGO
OMIM
CCDS CCDS11514
HPRD 05355
IMGT
EMBL
GenPept
RNA Seq Atlas