InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TRH

Summary

InnateDB Protein

IDBP-56262.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TRH

Protein Name

thyrotropin-releasing hormone

Synonyms

Pro-TRH; TRF;

Species

Homo sapiens

Ensembl Protein

ENSP00000303452

InnateDB Gene

IDBG-56260 (TRH)

Protein Structure

UniProt Annotation

Function

Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems. May promote hair shaft elongation, prolonge the hair cycle growth phase (anagen) and antagonized its termination by TGFB2. May also increase proliferation and inhibited apoptosis of hair matrix keratinocytes. {ECO:0000269PubMed:19825978}.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Hypothalamus. Expressed in the hair follicle epithelium (at protein level). {ECO:0000269PubMed:19825978}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	0
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005184	neuropeptide hormone activity
GO:0005515	protein binding
GO:0008437	thyrotropin-releasing hormone activity

Biological Process

GO:0001666	response to hypoxia
GO:0001692	histamine metabolic process
GO:0007165	signal transduction
GO:0007267	cell-cell signaling
GO:0007628	adult walking behavior
GO:0009409	response to cold
GO:0009749	response to glucose
GO:0009755	hormone-mediated signaling pathway
GO:0014050	negative regulation of glutamate secretion
GO:0014054	positive regulation of gamma-aminobutyric acid secretion
GO:0014070	response to organic cyclic compound
GO:0032024	positive regulation of insulin secretion
GO:0042755	eating behavior
GO:0045471	response to ethanol
GO:0051412	response to corticosterone
GO:2000252	negative regulation of feeding behavior