Homo sapiens Gene: TRH
Summary
InnateDB Gene IDBG-56260.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TRH
Gene Name thyrotropin-releasing hormone
Synonyms Pro-TRH; TRF;
Species Homo sapiens
Ensembl Gene ENSG00000170893
Encoded Proteins
thyrotropin-releasing hormone
thyrotropin-releasing hormone
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This hormone is responsible for the regulation and release of thyroid-stimulating hormone, as well as prolactin. Deficiency of this hormone has been associated with hypothalamic hypothyroidism. [provided by RefSeq, Sep 2010]
This gene encodes a member of the thyrotropin-releasing hormone family. Cleavage of the encoded proprotein releases mature thyrotropin-releasing hormone, which is a tripeptide hypothalamic regulatory hormone. The human proprotein contains six thyrotropin-releasing hormone tripeptides. Thyrotropin-releasing hormone is involved in the regulation and release of thyroid-stimulating hormone, as well as prolactin. Deficiency of this hormone has been associated with hypothalamic hypothyroidism. [provided by RefSeq, May 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:129974305-129977938
Strand Forward strand
Band q22.1
Transcripts
ENST00000302649 ENSP00000303452
ENST00000507066 ENSP00000426522
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 0
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005184 neuropeptide hormone activity
GO:0005515 protein binding
GO:0008437 thyrotropin-releasing hormone activity
Biological Process
GO:0001666 response to hypoxia
GO:0001692 histamine metabolic process
GO:0007165 signal transduction
GO:0007267 cell-cell signaling
GO:0007628 adult walking behavior
GO:0009409 response to cold
GO:0009749 response to glucose
GO:0009755 hormone-mediated signaling pathway
GO:0014050 negative regulation of glutamate secretion
GO:0014054 positive regulation of gamma-aminobutyric acid secretion
GO:0014070 response to organic cyclic compound
GO:0032024 positive regulation of insulin secretion
GO:0042755 eating behavior
GO:0045471 response to ethanol
GO:0051412 response to corticosterone
GO:2000252 negative regulation of feeding behavior
Cellular Component
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0030141 secretory granule
Orthologs
Species
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Pathways
NETPATH
REACTOME
Gastrin-CREB signalling pathway via PKC and MAPK pathway
Class A/1 (Rhodopsin-like receptors) pathway
G alpha (q) signalling events pathway
Signaling by GPCR pathway
Peptide ligand-binding receptors pathway
Signal Transduction pathway
GPCR downstream signaling pathway
GPCR ligand binding pathway
KEGG
INOH
GPCR signaling pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt P20396
TrEMBL
UniProt Splice Variant
Entrez Gene 7200
UniGene Hs.182231 Hs.732877
RefSeq NM_007117
HUGO HGNC:12298
OMIM 613879
CCDS CCDS3066
HPRD 08944
IMGT
EMBL AK313473 BC069375 BC074888 BC074889 BC110515 BC110516 CH471052 M63581 M63582
GenPept AAA36480 AAH69375 AAH74888 AAH74889 AAI10516 AAI10517 BAG36258 EAW79229
RNA Seq Atlas 7200