InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: TRH

Summary

InnateDB Gene

IDBG-56260.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TRH

Gene Name

thyrotropin-releasing hormone

Synonyms

Pro-TRH; TRF

Species

Homo sapiens

Ensembl Gene

ENSG00000170893

Encoded Proteins

IDBP-56262

thyrotropin-releasing hormone

IDBP-483457

thyrotropin-releasing hormone

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This hormone is responsible for the regulation and release of thyroid-stimulating hormone, as well as prolactin. Deficiency of this hormone has been associated with hypothalamic hypothyroidism. [provided by RefSeq, Sep 2010]
This gene encodes a member of the thyrotropin-releasing hormone family. Cleavage of the encoded proprotein releases mature thyrotropin-releasing hormone, which is a tripeptide hypothalamic regulatory hormone. The human proprotein contains six thyrotropin-releasing hormone tripeptides. Thyrotropin-releasing hormone is involved in the regulation and release of thyroid-stimulating hormone, as well as prolactin. Deficiency of this hormone has been associated with hypothalamic hypothyroidism. [provided by RefSeq, May 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:129974305-129977938

Strand

Forward strand

Band

q22.1

Transcripts

ENST00000302649	ENSP00000303452
ENST00000507066	ENSP00000426522

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	0
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005184	neuropeptide hormone activity
GO:0005515	protein binding
GO:0008437	thyrotropin-releasing hormone activity

Biological Process

GO:0001666	response to hypoxia
GO:0001692	histamine metabolic process
GO:0007165	signal transduction
GO:0007267	cell-cell signaling
GO:0007628	adult walking behavior
GO:0009409	response to cold
GO:0009749	response to glucose
GO:0009755	hormone-mediated signaling pathway
GO:0014050	negative regulation of glutamate secretion
GO:0014054	positive regulation of gamma-aminobutyric acid secretion
GO:0014070	response to organic cyclic compound
GO:0032024	positive regulation of insulin secretion
GO:0042755	eating behavior
GO:0045471	response to ethanol
GO:0051412	response to corticosterone
GO:2000252	negative regulation of feeding behavior