InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: WRNIP1

Summary

InnateDB Protein

IDBP-56448.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

WRNIP1

Protein Name

Werner helicase interacting protein 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000370146

InnateDB Gene

IDBG-56442 (WRNIP1)

Protein Structure

UniProt Annotation

Function

Functions as a modulator for initiation or reinitiation events during DNA polymerase delta-mediated DNA synthesis. Has an intrinsic ATPase activity that functions as a sensor of DNA damage or of arrested replication forks and regulates the extent of DNA synthesis. {ECO:0000269PubMed:15670210}.

Subcellular Localization

Nucleus {ECO:0000250}. Note=Colocalizes with WRN in granular structures in the nucleus. {ECO:0000250}.

Disease Associations

Tissue Specificity

Ubiquitously expressed. {ECO:0000269PubMed:11301316}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 37 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	37 [view]
Protein-Protein	34 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0009378	four-way junction helicase activity
GO:0016887	ATPase activity
GO:0042802	identical protein binding
GO:0046872	metal ion binding

Biological Process

GO:0000731	DNA synthesis involved in DNA repair
GO:0006200	ATP catabolic process
GO:0006260	DNA replication
GO:0006281	DNA repair
GO:0006310	DNA recombination
GO:0030174	regulation of DNA-dependent DNA replication initiation

Cellular Component

GO:0005634	nucleus
GO:0016020	membrane
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR002611 IstB-like ATP-binding protein
IPR003593 AAA+ ATPase domain
IPR003959 ATPase, AAA-type, core
IPR008533 Domain of unknown function DUF815
IPR008824 DNA helicase, Holliday junction RuvB type, N-terminal
IPR011704 ATPase, dynein-related, AAA domain
IPR021886 MgsA AAA+ ATPase C-terminal
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM