InnateDB Protein
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IDBP-56450.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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WRNIP1
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Protein Name
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Werner helicase interacting protein 1
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000370141
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InnateDB Gene
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IDBG-56442 (WRNIP1)
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Protein Structure
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Function |
Functions as a modulator for initiation or reinitiation events during DNA polymerase delta-mediated DNA synthesis. Has an intrinsic ATPase activity that functions as a sensor of DNA damage or of arrested replication forks and regulates the extent of DNA synthesis. {ECO:0000269PubMed:15670210}.
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Subcellular Localization |
Nucleus {ECO:0000250}. Note=Colocalizes with WRN in granular structures in the nucleus. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Ubiquitously expressed. {ECO:0000269PubMed:11301316}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 37 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated |
Total |
37
[view]
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Protein-Protein |
34
[view]
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Protein-DNA |
3
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
2 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR021886
MgsA AAA+ ATPase C-terminal
IPR027417
P-loop containing nucleoside triphosphate hydrolase
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PFAM |
PF12002
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q96S55
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PhosphoSite |
PhosphoSite-Q96S55
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
56897
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UniGene |
Hs.236828
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RefSeq |
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HUGO |
HGNC:20876
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OMIM |
608196
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CCDS |
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HPRD |
10494
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IMGT |
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EMBL |
AB056152
AB209723
AF218313
AK026179
AK223593
AK315471
AL139092
BC018923
CH471087
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GenPept |
AAF80563
AAH18923
BAB15383
BAB60709
BAD92960
BAD97313
BAG37857
CAH73663
CAH73664
CAH73665
CAH73666
EAW55087
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