Homo sapiens Protein: PVR | |||||||||||||||||||
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Summary | |||||||||||||||||||
InnateDB Protein | IDBP-56490.7 | ||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
Gene Symbol | PVR | ||||||||||||||||||
Protein Name | poliovirus receptor | ||||||||||||||||||
Synonyms | CD155; HVED; Necl-5; NECL5; PVS; TAGE4; | ||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||
Ensembl Protein | ENSP00000340870 | ||||||||||||||||||
InnateDB Gene | IDBG-56486 (PVR) | ||||||||||||||||||
Protein Structure | |||||||||||||||||||
UniProt Annotation | |||||||||||||||||||
Function | Mediates NK cell adhesion and triggers NK cell effector functions. Binds two different NK cell receptors: CD96 and CD226. These interactions accumulates at the cell-cell contact site, leading to the formation of a mature immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of lytic granules and IFN-gamma and activate cytoxicity of activated NK cells. May also promote NK cell-target cell modular exchange, and PVR transfer to the NK cell. This transfer is more important in some tumor cells expressing a lot of PVR, and may trigger fratricide NK cell activation, providing tumors with a mechanism of immunoevasion. Plays a role in mediating tumor cell invasion and migration. Serves as a receptor for poliovirus attachment to target cells. May play a role in axonal transport of poliovirus, by targeting virion-PVR-containing endocytic vesicles to the microtubular network through interaction with DYNLT1. This interaction would drive the virus-containing vesicle to the axonal retrograde transport. {ECO:0000269PubMed:15471548, ECO:0000269PubMed:15607800}. | ||||||||||||||||||
Subcellular Localization | Isoform Alpha: Cell membrane; Single-pass type I membrane protein.Isoform Delta: Cell membrane; Single-pass type I membrane protein.Isoform Beta: Secreted.Isoform Gamma: Secreted. | ||||||||||||||||||
Disease Associations | |||||||||||||||||||
Tissue Specificity | |||||||||||||||||||
Comments | |||||||||||||||||||
Interactions | |||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||
PDB ID | |||||||||||||||||||
InterPro |
IPR003596
Immunoglobulin V-set, subgroup IPR003599 Immunoglobulin subtype IPR007110 Immunoglobulin-like domain IPR013106 Immunoglobulin V-set domain IPR013151 Immunoglobulin IPR013162 CD80-like, immunoglobulin C2-set |
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PFAM |
PF07686
PF00047 PF08205 |
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PRINTS | |||||||||||||||||||
PIRSF | |||||||||||||||||||
SMART |
SM00406
SM00409 |
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TIGRFAMs | |||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||
Modification | |||||||||||||||||||
Cross-References | |||||||||||||||||||
SwissProt | P15151 | ||||||||||||||||||
PhosphoSite | PhosphoSite-P15151 | ||||||||||||||||||
TrEMBL | |||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||
Entrez Gene | 5817 | ||||||||||||||||||
UniGene | Hs.619496 | ||||||||||||||||||
RefSeq | NP_001129241 | ||||||||||||||||||
HUGO | HGNC:9705 | ||||||||||||||||||
OMIM | 173850 | ||||||||||||||||||
CCDS | CCDS46106 | ||||||||||||||||||
HPRD | 01434 | ||||||||||||||||||
IMGT | |||||||||||||||||||
EMBL | AC068948 AK300349 BC015542 M24406 M24407 X64116 X64117 X64118 X64119 X64120 X64121 X64122 X64123 | ||||||||||||||||||
GenPept | AAA36461 AAA36462 AAF69803 AAH15542 BAG62091 CAA45478 CAA45479 CAA45480 | ||||||||||||||||||