InnateDB Protein
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IDBP-56498.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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TM7SF2
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Protein Name
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transmembrane 7 superfamily member 2
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Synonyms
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ANG1; DHCR14A; NET47;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000329520
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InnateDB Gene
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IDBG-56494 (TM7SF2)
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Protein Structure
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Function |
Involved in the conversion of lanosterol to cholesterol. {ECO:0000269PubMed:11784322}.
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Subcellular Localization |
Microsome membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000269PubMed:9878250}; Multi-pass membrane protein {ECO:0000269PubMed:9878250}.
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Disease Associations |
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Tissue Specificity |
Expressed in adult heart, brain, pancreas, lung, liver, skeletal muscle, kidney, ovary, prostate, and testis, but not detected in placenta, spleen, thymus, small intestine, colon (mucosal lining), or peripheral blood leukocytes. {ECO:0000269PubMed:9878250}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
6
[view]
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Protein-Protein |
5
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0016628
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oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
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GO:0050613
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delta14-sterol reductase activity
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001171
Ergosterol biosynthesis ERG4/ERG24
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PFAM |
PF01222
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
O76062
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PhosphoSite |
PhosphoSite-
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TrEMBL |
E9PRQ1
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UniProt Splice Variant |
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Entrez Gene |
7108
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UniGene |
Hs.31130
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RefSeq |
NP_001264162
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HUGO |
HGNC:11863
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OMIM |
603414
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CCDS |
CCDS60846
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HPRD |
04564
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IMGT |
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EMBL |
AF023676
AF048704
AF096303
AF096304
AK290935
AP003068
BC009052
BC012857
BC038353
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GenPept |
AAC21450
AAC21457
AAD09765
AAD09769
AAH09052
AAH12857
AAH38353
BAF83624
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