InnateDB Protein
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IDBP-56585.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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HMMR
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Protein Name
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hyaluronan-mediated motility receptor (RHAMM)
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Synonyms
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CD168; IHABP; RHAMM;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000185942
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InnateDB Gene
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IDBG-56581 (HMMR)
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Protein Structure
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Function |
Involved in cell motility. When hyaluronan binds to HMMR, the phosphorylation of a number of proteins, including PTK2/FAK1 occurs. May also be involved in cellular transformation and metastasis formation, and in regulating extracellular- regulated kinase (ERK) activity.
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Subcellular Localization |
Cell surface. Cytoplasm {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Expressed in breast cancer cell lines and in normal breast tissue.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
33
[view]
|
Protein-Protein |
29
[view]
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Protein-DNA |
4
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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|
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Molecular Function |
Accession |
GO Term |
GO:0005540
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hyaluronic acid binding
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
O75330
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PhosphoSite |
PhosphoSite-O75330
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TrEMBL |
E5RIH2
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UniProt Splice Variant |
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Entrez Gene |
3161
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UniGene |
Hs.740467
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RefSeq |
NP_036617
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HUGO |
HGNC:5012
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OMIM |
600936
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CCDS |
CCDS4363
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HPRD |
02963
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IMGT |
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EMBL |
AC112205
AF032862
AK290577
AK303616
BC108904
CH471062
EU526024
U29343
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GenPept |
AAC32548
AAC52049
AAI08905
ACD35245
BAF83266
BAG64626
EAW61522
EAW61523
EAW61524
EAW61525
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