InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: OVOL2

Summary

InnateDB Protein

IDBP-56806.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

OVOL2

Protein Name

ovo-like 2 (Drosophila)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000278780

InnateDB Gene

IDBG-56804 (OVOL2)

Protein Structure

UniProt Annotation

Function

Zinc-finger transcription repressor factor. Plays a critical role to maintain the identity of epithelial lineages by suppressing epithelial-to mesenchymal transition mainly through the up-regulation of ZEB1 expression. Positively regulates neuronal differentiation (By similarity). Suppresses cell cycling and terminal differentiation of keratinocytes by directly repressing MYC and NOTCH1. {ECO:0000250, ECO:0000269PubMed:19700410}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in testis, ovary, heart and skeletal muscle. {ECO:0000269PubMed:12213202}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0003677	DNA binding
GO:0044212	transcription regulatory region DNA binding
GO:0046872	metal ion binding

Biological Process

GO:0001525	angiogenesis
GO:0001755	neural crest cell migration
GO:0001842	neural fold formation
GO:0001947	heart looping
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0007507	heart development
GO:0008285	negative regulation of cell proliferation
GO:0009953	dorsal/ventral pattern formation
GO:0010719	negative regulation of epithelial to mesenchymal transition
GO:0010837	regulation of keratinocyte proliferation
GO:0010944	negative regulation of transcription by competitive promoter binding
GO:0045617	negative regulation of keratinocyte differentiation
GO:0045746	negative regulation of Notch signaling pathway
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0048557	embryonic digestive tract morphogenesis
GO:0051726	regulation of cell cycle
GO:0060214	endocardium formation
GO:0060347	heart trabecula formation
GO:0060716	labyrinthine layer blood vessel development