InnateDB Protein
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IDBP-57090.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SCYL1
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Protein Name
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SCY1-like 1 (S. cerevisiae)
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000279270
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InnateDB Gene
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IDBG-57084 (SCYL1)
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Protein Structure
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Function |
Regulates COPI-mediated retrograde traffic. Has no detectable kinase activity in vitro. {ECO:0000269PubMed:18556652}.Isoform 6 acts as transcriptional activator. It binds to three different types of GC-rich DNA binding sites (box-A, -B and -C) in the beta-polymerase promoter region. It also binds to the TERT promoter region. {ECO:0000269PubMed:18556652}.
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Subcellular Localization |
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269PubMed:18556652}. Endoplasmic reticulum-Golgi intermediate compartment {ECO:0000269PubMed:18556652}. Golgi apparatus, cis-Golgi network {ECO:0000269PubMed:18556652}. Note=Localized to the Endoplasmic reticulum-Golgi intermediate and cis-Golgi in an ARF1-independent manner.Isoform 1: Cytoplasm. Note=Cytoplasmic throughout the cell cycle.Isoform 2: Cytoplasm. Note=Cytoplasmic throughout the cell cycle.Isoform 3: Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Cytoplasmic during interphase and centrosomal during mitosis, it localizes to the centrosomes in a microtubule-independent manner.Isoform 6: Nucleus {ECO:0000269PubMed:15504359}.
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Disease Associations |
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Tissue Specificity |
Ubiquitous. {ECO:0000269PubMed:12036289}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
12
[view]
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Protein-Protein |
11
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
1
[view]
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
GO:0006351
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transcription, DNA-templated
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GO:0006355
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regulation of transcription, DNA-templated
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GO:0006890
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retrograde vesicle-mediated transport, Golgi to ER
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GO:0018108
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peptidyl-tyrosine phosphorylation
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Cellular Component |
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PDB ID |
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InterPro |
IPR000357
HEAT
IPR016024
Armadillo-type fold
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PFAM |
PF02985
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q96KG9
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PhosphoSite |
PhosphoSite-Q96KG9
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
57410
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UniGene |
Hs.238839
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RefSeq |
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HUGO |
HGNC:14372
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OMIM |
607982
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CCDS |
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HPRD |
06414
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IMGT |
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EMBL |
AB047077
AB051427
AB051428
AF225424
AF255613
AF297709
AP000769
BC009967
BC069233
CH471076
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GenPept |
AAF81422
AAG09726
AAG17902
AAH09967
AAH69233
BAB55454
BAB55458
BAB55459
EAW74399
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