Homo sapiens Gene: SCYL1
Summary
InnateDB Gene IDBG-57084.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SCYL1
Gene Name SCY1-like 1 (S. cerevisiae)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000142186
Encoded Proteins
SCY1-like 1 (S. cerevisiae)
SCY1-like 1 (S. cerevisiae)
SCY1-like 1 (S. cerevisiae)
SCY1-like 1 (S. cerevisiae)
SCY1-like 1 (S. cerevisiae)
SCY1-like 1 (S. cerevisiae)
SCY1-like 1 (S. cerevisiae)
SCY1-like 1 (S. cerevisiae)
SCY1-like 1 (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a transcriptional regulator belonging to the SCY1-like family of kinase-like proteins. The protein has a divergent N-terminal kinase domain that is thought to be catalytically inactive, and can bind specific DNA sequences through its C-terminal domain. It activates transcription of the telomerase reverse transcriptase and DNA polymerase beta genes. The protein has been localized to the nucleus, and also to the cytoplasm and centrosomes during mitosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:65525077-65538704
Strand Forward strand
Band q13.1
Transcripts
ENST00000270176 ENSP00000270176
ENST00000279270 ENSP00000279270
ENST00000420247 ENSP00000408192
ENST00000525364 ENSP00000431635
ENST00000533862 ENSP00000437254
ENST00000524944 ENSP00000432175
ENST00000527009 ENSP00000436993
ENST00000529178
ENST00000531601 ENSP00000431664
ENST00000524897
ENST00000526454
ENST00000529981
ENST00000528545 ENSP00000433604
ENST00000534462
ENST00000532290
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005488 binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006468 protein phosphorylation
GO:0006890 retrograde vesicle-mediated transport, Golgi to ER
GO:0018108 peptidyl-tyrosine phosphorylation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment
GO:0005794 Golgi apparatus
GO:0005801 cis-Golgi network
GO:0005815 microtubule organizing center
GO:0016020 membrane
GO:0030126 COPI vesicle coat
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.238839
RefSeq NM_001048218 NM_020680 XM_005274118 XM_005274120 XM_005274121
HUGO
OMIM
CCDS CCDS41672 CCDS44646
HPRD 06414
IMGT
EMBL
GenPept
RNA Seq Atlas