InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SCYL1

Summary

InnateDB Gene

IDBG-57084.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SCYL1

Gene Name

SCY1-like 1 (S. cerevisiae)

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000142186

Encoded Proteins

IDBP-57088

SCY1-like 1 (S. cerevisiae)

IDBP-57090

SCY1-like 1 (S. cerevisiae)

IDBP-378355

SCY1-like 1 (S. cerevisiae)

IDBP-587359

SCY1-like 1 (S. cerevisiae)

IDBP-596407

SCY1-like 1 (S. cerevisiae)

IDBP-595387

SCY1-like 1 (S. cerevisiae)

IDBP-598282

SCY1-like 1 (S. cerevisiae)

IDBP-584773

SCY1-like 1 (S. cerevisiae)

IDBP-599331

SCY1-like 1 (S. cerevisiae)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a transcriptional regulator belonging to the SCY1-like family of kinase-like proteins. The protein has a divergent N-terminal kinase domain that is thought to be catalytically inactive, and can bind specific DNA sequences through its C-terminal domain. It activates transcription of the telomerase reverse transcriptase and DNA polymerase beta genes. The protein has been localized to the nucleus, and also to the cytoplasm and centrosomes during mitosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:65525077-65538704

Strand

Forward strand

Band

q13.1

Transcripts

ENST00000270176	ENSP00000270176
ENST00000279270	ENSP00000279270
ENST00000420247	ENSP00000408192
ENST00000525364	ENSP00000431635
ENST00000533862	ENSP00000437254
ENST00000524944	ENSP00000432175
ENST00000527009	ENSP00000436993
ENST00000529178
ENST00000531601	ENSP00000431664
ENST00000524897
ENST00000526454
ENST00000529981
ENST00000528545	ENSP00000433604
ENST00000534462
ENST00000532290

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005488	binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006468	protein phosphorylation
GO:0006890	retrograde vesicle-mediated transport, Golgi to ER
GO:0018108	peptidyl-tyrosine phosphorylation

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005793	endoplasmic reticulum-Golgi intermediate compartment
GO:0005794	Golgi apparatus
GO:0005801	cis-Golgi network
GO:0005815	microtubule organizing center
GO:0016020	membrane
GO:0030126	COPI vesicle coat

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000024941

View Gene Order

ENSBTAG00000006740

Not yet available

Cross-References

SwissProt

Q96KG9

TrEMBL

E9PPN3

UniProt Splice Variant

Entrez Gene

57410

UniGene

Hs.238839

RefSeq

NM_020680 XM_005274118 NM_001048218 XM_005274120 XM_005274121

HUGO

HGNC:14372

OMIM

607982

CCDS

CCDS41672 CCDS44646

HPRD

06414

IMGT

EMBL

AB047077 AB051427 AB051428 AF225424 AF255613 AF297709 AP000769 BC009967 BC069233 CH471076

GenPept

AAF81422 AAG09726 AAG17902 AAH09967 AAH69233 BAB55454 BAB55458 BAB55459 EAW74399

RNA Seq Atlas

57410