Version 5.4
Homo sapiens Protein: NQO2
Summary
InnateDB Protein IDBP-57151.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NQO2
Protein Name NAD(P)H dehydrogenase, quinone 2
Synonyms DHQV; DIA6; NMOR2; QR2;
Species Homo sapiens
Ensembl Protein ENSP00000369822
InnateDB Gene IDBG-57147 (NQO2)
Protein Structure
UniProt Annotation
Function The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis. {ECO:0000269PubMed:18254726}.
Subcellular Localization Cytoplasm.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
Experimentally validated
Total 19 [view]
Protein-Protein 17 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0001512 dihydronicotinamide riboside quinone reductase activity
GO:0008753 NADPH dehydrogenase (quinone) activity
GO:0009055 electron carrier activity
GO:0016491 oxidoreductase activity
GO:0046872 metal ion binding
Biological Process
GO:0007613 memory
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR003680 Flavodoxin-like fold
IPR005025 NADPH-dependent FMN reductase-like
IPR029039 Flavoprotein-like
PFAM PF02525
PF03358
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P16083
PhosphoSite PhosphoSite-P16083
TrEMBL Q5TD05
UniProt Splice Variant
Entrez Gene 4835
UniGene Hs.533050
RefSeq NP_000895
HUGO HGNC:7856
OMIM 160998
CCDS CCDS4481
HPRD 01190
IMGT
EMBL AB050248 AK311746 AL133351 AY299456 AY855291 BC006096 CH471087 J02888
GenPept AAA60239 AAB60642 AAH06096 AAW29945 BAB16974 BAG34689 CAI23294 EAW55107

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca