Version 5.4
Homo sapiens Gene: NQO2
Summary
InnateDB Gene IDBG-57147.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NQO2
Gene Name NAD(P)H dehydrogenase, quinone 2
Synonyms DHQV; DIA6; NMOR2; QR2
Species Homo sapiens
Ensembl Gene ENSG00000124588
Encoded Proteins
IDBP-57149
NAD(P)H dehydrogenase, quinone 2
IDBP-57151
NAD(P)H dehydrogenase, quinone 2
IDBP-57153
NAD(P)H dehydrogenase, quinone 2
IDBP-57155
NAD(P)H dehydrogenase, quinone 2
IDBP-57157
NAD(P)H dehydrogenase, quinone 2
IDBP-57159
NAD(P)H dehydrogenase, quinone 2
IDBP-234742
NAD(P)H dehydrogenase, quinone 2
IDBP-360733
NAD(P)H dehydrogenase, quinone 2
IDBP-811984
NAD(P)H dehydrogenase, quinone 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary NQO2 (EC 1.10.99.2) is a flavoprotein that catalyzes the 2-electron reduction of various quinones, redox dyes, and the vitamin K menadione. NQO2 predominantly uses dihydronicotinamide riboside (NRH) as the electron donor (summary by Wu et al., 1997 [PubMed 9367528]).[supplied by OMIM, Jul 2010]
This gene encodes a member of the thioredoxin family of enzymes. It is a cytosolic and ubiquitously expressed flavoprotein that catalyzes the two-electron reduction of quinone substrates and uses dihydronicotinamide riboside as a reducing coenzyme. Mutations in this gene have been associated with neurodegenerative diseases and several cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:2987987-3028869
Strand Forward strand
Band p25.2
Transcripts
ENST00000380472 ENSP00000369839
ENST00000380455 ENSP00000369822
ENST00000380454 ENSP00000369821
ENST00000338130 ENSP00000337773
ENST00000380441 ENSP00000369806
ENST00000380430 ENSP00000369795
ENST00000397717 ENSP00000380829
ENST00000426637 ENSP00000406951
ENST00000606474 ENSP00000475864
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
Experimentally validated
Total 19 [view]
Protein-Protein 17 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0001512 dihydronicotinamide riboside quinone reductase activity
GO:0008753 NADPH dehydrogenase (quinone) activity
GO:0009055 electron carrier activity
GO:0016491 oxidoreductase activity
GO:0046872 metal ion binding
Biological Process
GO:0007613 memory
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000046949
View Gene Order
ENSBTAG00000000786
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.533050
RefSeq NM_000904 NM_001290221 NM_001290222 XM_005249151
HUGO
OMIM
CCDS CCDS4481 CCDS75388
HPRD 01190
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca