Homo sapiens Gene: NQO2
Summary
InnateDB Gene IDBG-57147.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NQO2
Gene Name NAD(P)H dehydrogenase, quinone 2
Synonyms DHQV; DIA6; NMOR2; QR2;
Species Homo sapiens
Ensembl Gene ENSG00000124588
Encoded Proteins
NAD(P)H dehydrogenase, quinone 2
NAD(P)H dehydrogenase, quinone 2
NAD(P)H dehydrogenase, quinone 2
NAD(P)H dehydrogenase, quinone 2
NAD(P)H dehydrogenase, quinone 2
NAD(P)H dehydrogenase, quinone 2
NAD(P)H dehydrogenase, quinone 2
NAD(P)H dehydrogenase, quinone 2
NAD(P)H dehydrogenase, quinone 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary NQO2 (EC 1.10.99.2) is a flavoprotein that catalyzes the 2-electron reduction of various quinones, redox dyes, and the vitamin K menadione. NQO2 predominantly uses dihydronicotinamide riboside (NRH) as the electron donor (summary by Wu et al., 1997 [PubMed 9367528]).[supplied by OMIM, Jul 2010]
This gene encodes a member of the thioredoxin family of enzymes. It is a cytosolic and ubiquitously expressed flavoprotein that catalyzes the two-electron reduction of quinone substrates and uses dihydronicotinamide riboside as a reducing coenzyme. Mutations in this gene have been associated with neurodegenerative diseases and several cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:2987987-3028869
Strand Forward strand
Band p25.2
Transcripts
ENST00000380472 ENSP00000369839
ENST00000380455 ENSP00000369822
ENST00000380454 ENSP00000369821
ENST00000338130 ENSP00000337773
ENST00000380441 ENSP00000369806
ENST00000380430 ENSP00000369795
ENST00000397717 ENSP00000380829
ENST00000426637 ENSP00000406951
ENST00000606474 ENSP00000475864
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
Experimentally validated
Total 19 [view]
Protein-Protein 17 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0001512 dihydronicotinamide riboside quinone reductase activity
GO:0008753 NADPH dehydrogenase (quinone) activity
GO:0009055 electron carrier activity
GO:0016491 oxidoreductase activity
GO:0046872 metal ion binding
Biological Process
GO:0007613 memory
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Cross-References
SwissProt P16083
TrEMBL A2A2U4 Q5TD05
UniProt Splice Variant
Entrez Gene 4835
UniGene Hs.533050
RefSeq NM_001290221 NM_000904 NM_001290222 XM_005249151
HUGO HGNC:7856
OMIM 160998
CCDS CCDS4481 CCDS75388
HPRD 01190
IMGT
EMBL AB050248 AK311746 AL133351 AY299456 AY855291 BC006096 CH471087 J02888
GenPept AAA60239 AAB60642 AAH06096 AAW29945 BAB16974 BAG34689 CAI23294 EAW55107
RNA Seq Atlas 4835