InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: POLR3F

Summary

InnateDB Protein

IDBP-57195.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

POLR3F

Protein Name

polymerase (RNA) III (DNA directed) polypeptide F, 39 kDa

Synonyms

RPC39; RPC6;

Species

Homo sapiens

Ensembl Protein

ENSP00000366828

InnateDB Gene

IDBG-57193 (POLR3F)

Protein Structure

UniProt Annotation

Function

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct RNA Pol III binding to the TFIIIB-DNA complex. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway. {ECO:0000269PubMed:19609254, ECO:0000269PubMed:19631370}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 30 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	30 [view]
Protein-Protein	29 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001056	RNA polymerase III activity
GO:0003677	DNA binding
GO:0003899	DNA-directed RNA polymerase activity
GO:0005515	protein binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006359	regulation of transcription from RNA polymerase III promoter
GO:0006383	transcription from RNA polymerase III promoter
GO:0006385	transcription elongation from RNA polymerase III promoter
GO:0006386	termination of RNA polymerase III transcription
GO:0010467	gene expression
GO:0032481	positive regulation of type I interferon production
GO:0032728	positive regulation of interferon-beta production
GO:0045087	innate immune response
GO:0045089	positive regulation of innate immune response
GO:0051607	defense response to virus