InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CALCOCO2

Summary

InnateDB Protein

IDBP-57246.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CALCOCO2

Protein Name

calcium binding and coiled-coil domain 2

Synonyms

NDP52;

Species

Homo sapiens

Ensembl Protein

ENSP00000258947

InnateDB Gene

IDBG-57242 (CALCOCO2)

Protein Structure

UniProt Annotation

Function

May play a role in ruffle formation and actin cytoskeleton organization. Seems to negatively regulate constitutive secretion. {ECO:0000269PubMed:17635994}.

Subcellular Localization

Cytoplasm, perinuclear region. Golgi apparatus. Cytoplasm, cytoskeleton. Note=According to PubMed:7540613, localizes to nuclear dots. According to PubMed:9230084 and PubMed:12869526, it is not a nuclear dot- associated protein but localizes predominantly in the cytoplasm with a coarse-grained distribution preferentially close to the nucleus.

Disease Associations

Tissue Specificity

Expressed in all tissues tested with highest expression in skeletal muscle and lowest in brain. {ECO:0000269PubMed:7540613}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 110 experimentally validated interaction(s) in this database.

Experimentally validated
Total	110 [view]
Protein-Protein	110 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0016032	viral process
GO:0034341	response to interferon-gamma
GO:0045087	innate immune response (InnateDB)

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0005856	cytoskeleton
GO:0016020	membrane
GO:0043231	intracellular membrane-bounded organelle
GO:0048471	perinuclear region of cytoplasm