Version 5.4
Homo sapiens Gene: CALCOCO2
Summary
InnateDB Gene IDBG-57242.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CALCOCO2
Gene Name calcium binding and coiled-coil domain 2
Synonyms NDP52
Species Homo sapiens
Ensembl Gene ENSG00000136436
Encoded Proteins
IDBP-57246
calcium binding and coiled-coil domain 2
IDBP-380616
calcium binding and coiled-coil domain 2
IDBP-380617
calcium binding and coiled-coil domain 2
IDBP-484916
calcium binding and coiled-coil domain 2
IDBP-478568
calcium binding and coiled-coil domain 2
IDBP-475489
calcium binding and coiled-coil domain 2
IDBP-474448
calcium binding and coiled-coil domain 2
IDBP-477891
calcium binding and coiled-coil domain 2
IDBP-479458
calcium binding and coiled-coil domain 2
IDBP-481469
calcium binding and coiled-coil domain 2
IDBP-480385
calcium binding and coiled-coil domain 2
IDBP-480218
calcium binding and coiled-coil domain 2
IDBP-763114
IDBP-763227
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 19820708
CALCOCO2 recognizes ubiquitin-coated Salmonella enterica in human cells and binds to the adaptor proteins AZI2 and TBKBP1 to recruit TBK1. CALCOCO2 also recruits LC3, an autophagosomal marker, to activate autophagy against bacteria attempting to colonize their cytosol.
PMID 20104023
CALCOCO2 is a novel receptor for the selective autophagy of cytosolic bacteria. CALCOCO2 (NDP52) binds to the bacterial ubiquitin coat as well as to ATG8/LC3 and delivers cytosolic bacteria into autophagosomes.
PMID 19841643
CALCOCO2 directly binds to ubiquitinated bacteria and facilitates the assembly of an autophagic membrane that surrounds bacterial invaders.
PMID 22901810
CALCOCO2 and SQSTM1 are ubiquitin-autophagy receptors that are required for the recognition of extracelluar bacterial DNA by the TMEM173 (STING)-dependent cytosolic pathway, marking bacteria with ubiquitin, and delivery of bacilli to autophagosomes. (Demonstrated in mouse)
PMID 23022382
MAP1LC3C (LC3C) and its receptor CALCOCO2 (NDP52) are essential for antibacterial autophagy.
InnateDB Annotation from Orthologs
Summary
PMID 22901810
[Mus musculus] Calcoco2 and Sqstm1 are ubiquitin-autophagy receptors that are required for the recognition of extracelluar bacterial DNA by the Tmem173 (STING)-dependent cytosolic pathway, marking bacteria with ubiquitin, and delivery of bacilli to autophagosomes.
Entrez Gene
Summary This gene encodes a coiled-coil domain-containing protein. The encoded protein functions as a receptor for ubiquitin-coated bacteria and plays an important role in innate immunity by mediating macroautophagy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:48830988-48866522
Strand Forward strand
Band q21.32
Transcripts
ENST00000258947 ENSP00000258947
ENST00000372317
ENST00000448105 ENSP00000398523
ENST00000416445 ENSP00000406974
ENST00000503463
ENST00000509507 ENSP00000424352
ENST00000510356
ENST00000509415 ENSP00000425692
ENST00000513119 ENSP00000425090
ENST00000508679 ENSP00000423437
ENST00000511697
ENST00000505071 ENSP00000422697
ENST00000507076 ENSP00000424169
ENST00000502761 ENSP00000424889
ENST00000509014
ENST00000514962
ENST00000514267
ENST00000514006
ENST00000511816
ENST00000509112
ENST00000506971
ENST00000507306 ENSP00000424083
ENST00000509784 ENSP00000429963
ENST00000510997
ENST00000576582 ENSP00000461184
ENST00000575560
ENST00000575461
ENST00000570513 ENSP00000461083
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 110 experimentally validated interaction(s) in this database.
Experimentally validated
Total 110 [view]
Protein-Protein 110 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0016032 viral process
GO:0034341 response to interferon-gamma
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005856 cytoskeleton
GO:0016020 membrane
GO:0043231 intracellular membrane-bounded organelle
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000006056
View Gene Order
ENSBTAG00000007935
Not yet available
Pathways
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.514920 Hs.622495 Hs.624928
RefSeq NM_001261390 NM_001261391 NM_001261393 NM_001261395 NM_005831
HUGO
OMIM
CCDS CCDS11538 CCDS58558 CCDS58559 CCDS58560 CCDS58561
HPRD 06846
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca