InnateDB Protein
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IDBP-57414.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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BPHL
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Protein Name
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biphenyl hydrolase-like (serine hydrolase)
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Synonyms
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BPH-RP; MCNAA; VACVASE;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000369739
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InnateDB Gene
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IDBG-57412 (BPHL)
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Protein Structure
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Function |
Serine hydrolase that catalyzes the hydrolytic activation of amino acid ester prodrugs of nucleoside analogs such as valacyclovir and valganciclovir. Activates valacyclovir to acyclovir. May play a role in detoxification processes. It is a specific alpha-amino acid ester hydrolase that prefers small, hydrophobic, and aromatic side chains and does not have a stringent requirement for the leaving group other than preferring a primary alcohol. {ECO:0000269PubMed:18256025}.
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Subcellular Localization |
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Disease Associations |
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Tissue Specificity |
Expressed at high levels in liver and kidney and lower levels in heart, intestine and skeletal muscle. {ECO:0000269PubMed:7759552}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
4
[view]
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Protein-Protein |
3
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000073
Alpha/beta hydrolase fold-1
IPR029058
Alpha/Beta hydrolase fold
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PFAM |
PF00561
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PRINTS |
PR00111
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q86WA6
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PhosphoSite |
PhosphoSite-Q86WA6
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
670
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UniGene |
Hs.733339
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RefSeq |
NP_004323
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HUGO |
HGNC:1094
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OMIM |
603156
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CCDS |
CCDS4483
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HPRD |
04403
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IMGT |
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EMBL |
AJ617684
AL031963
BC106901
CH471087
X57653
X81372
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GenPept |
AAI06902
CAA40859
CAA57137
CAD70626
CAD70627
CAE85120
EAW55122
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